| Gene Symbol |
CCDC39
|
| Entrez Gene |
339829
|
| Alt Symbol |
CILD14, FAP59
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coiled-coil domain containing 39
|
| Other Description |
coiled-coil domain-containing protein 39
|
| Swissprots |
Q9UFE4 B4E2H1
|
| Accessions |
Q9UFE4 AK304270 BAG65133 AL122120 CAB59277 BG205877 DC399927 NM_181426 NP_852091
|
| Function |
Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131972). Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly (PubMed:21131972). {ECO:0000250|UniProtKB:A8IQT2, ECO:0000269|PubMed:21131972}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:21131972, ECO:0000269|PubMed:21131974}. Note=CCDC40 is required for localization to axonemes. {ECO:0000269|PubMed:21131974}.
|
| Tissue Specificity |
Mainly expressed in nasal brushings and, to a lesser extent, in lungs and testis. {ECO:0000269|PubMed:21131972}.
|