Gene Symbol | CCDC39 |
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Entrez Gene | 339829 |
Alt Symbol | CILD14, FAP59 |
Species | Human |
Gene Type | protein-coding |
Description | coiled-coil domain containing 39 |
Other Description | coiled-coil domain-containing protein 39 |
Swissprots | Q9UFE4 B4E2H1 |
Accessions | Q9UFE4 AK304270 BAG65133 AL122120 CAB59277 BG205877 DC399927 NM_181426 NP_852091 |
Function | Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131972). Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly (PubMed:21131972). {ECO:0000250|UniProtKB:A8IQT2, ECO:0000269|PubMed:21131972}. |
Subcellular Location | Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:21131972, ECO:0000269|PubMed:21131974}. Note=CCDC40 is required for localization to axonemes. {ECO:0000269|PubMed:21131974}. |
Tissue Specificity | Mainly expressed in nasal brushings and, to a lesser extent, in lungs and testis. {ECO:0000269|PubMed:21131972}. |
CCDC39 CRISPR/Cas9 KO Plasmid (h) - sc-415527 from Santa Cruz Biotechnology
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CCDC39 HDR Plasmid (h) - sc-415527-HDR from Santa Cruz Biotechnology
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CCDC39 Double Nickase Plasmid (h) - sc-415527-NIC from Santa Cruz Biotechnology
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CCDC39 Double Nickase Plasmid (h2) - sc-415527-NIC-2 from Santa Cruz Biotechnology
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CCDC39 CRISPR Activation Plasmid (h) - sc-415527-ACT from Santa Cruz Biotechnology
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CCDC39 CRISPR Activation Plasmid (h2) - sc-415527-ACT-2 from Santa Cruz Biotechnology
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CCDC39 Lentiviral Activation Particles (h) - sc-415527-LAC from Santa Cruz Biotechnology
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CCDC39 Lentiviral Activation Particles (h2) - sc-415527-LAC-2 from Santa Cruz Biotechnology
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CCDC39 siRNA (h) - sc-77992 from Santa Cruz Biotechnology
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CCDC39 shRNA Plasmid (h) - sc-77992-SH from Santa Cruz Biotechnology
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CCDC39 shRNA (h) Lentiviral Particles - sc-77992-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU152491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5524 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5524 from Sigma-Aldrich
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CCDC39 siRNA (Human) - CRJ7311 from Cohesion Biosciences
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CCDC39 - MBS8201924 from MyBioSource
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shRNA set against Human CCDC39 (NM_181426.1) - SHH256621 from Creative biogene
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Human CCDC39 siRNA - orb277812 from Biorbyt
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CCDC39 shRNA Plasmid (Human) - CHJ7311 from Cohesion Biosciences
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