SNX18

Gene Symbol SNX18
Entrez Gene 112574
Alt Symbol SH3PX2, SH3PXD3B, SNAG1
Species Human
Gene Type protein-coding
Description sorting nexin 18
Other Description SH3 and PX domain-containing protein 3B|sorting nexin associated golgi protein 1|sorting nexin-18|sorting nexin-associated Golgi protein 1
Swissprots Q0VG02 Q05BB3 B4E2B3 Q96RF0 H7BXX3
Accessions EAW54894 Q96RF0 AF395536 AAK82415 AI335241 AI669182 AK022059 AK057122 AK304195 BAG65075 BC060791 AAH60791 BC067860 AAH67860 BC117218 AAI17219 BC117220 AAI17221 BJ990551 BJ990552 CD722181 CN360136 CN479485 NM_001102575 NP_001096045 NM_001145427 NP_001138899 NM_052870 NP_443102
Function Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane. {ECO:0000269|PubMed:18411244, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}.
Subcellular Location Endomembrane system; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Partially colocalized with clathrin and dynamin at the cell membrane. Transiently recruited to clathrin- coated pits at a late stage of clathrin-coated vesicle formation.

SNX18 (E-16) - sc-165518 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SNX18 antibody - ab111702 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-SNX18 antibody (ab111702) at 1/5000 dilution + A549 whole cell lysate at 30 µg

Anti-SNX18 antibody - ab96843 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SNX18 antibody (ab96843) at 1/1000 dilutionLane 1 : H1299 whole cell lysateLane 2 : HeLa whole cell lysateLysates/proteins at 30 µg per lane.

Anti-SNX18 antibody - ab99035 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SNX18 antibody (ab99035) at 1 µg/ml + 721_B cell lysate at 10 µg

Anti-SNX18 antibody - ab3941 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-SNX18 antibody (ab3941) at 1 µg/ml + A549 cell lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-SNX18 antibody - C-terminal - ab173009 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SNX18 antibody - C-terminal (ab173009) at 1/100 dilution + WiDr cell line lysate at 35 µg

Anti-SNX18 Antibody (aa566-628) - LS-C185789 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded MDAMB231 xenograft using SNX18 antibody at 1:500 dilution.

Anti-SNX18 Antibody (aa616-628) - LS-C55502 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SNX18 Antibody (aa485-514, AP) - LS-C241062 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNX18 Antibody (aa485-514, APC) - LS-C241064 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNX18 Antibody (aa485-514, Biotin) - LS-C241065 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNX18 Antibody (aa485-514, FITC) - LS-C241066 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNX18 Antibody (aa485-514, PE) - LS-C241069 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNX18 Antibody (aa484-514) - LS-C325252 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNX18 Antibody (aa485-514, Azide-free, HRP) - LS-C248214 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SNX18 Antibody (aa107-156) - LS-C108092 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SNX18 antibody LS-C108092 Western blot of 721_B cell lysate.

Anti-SNX18 Antibody (aa371-420) - LS-C116920 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SNX18 antibody LS-C116920 Western blot of A549 cell lysate.

Anti-SNX18 Antibody (aa492-541) - LS-C117092 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SNX18 antibody LS-C117092 Western blot of Placenta lysate.

Anti-SNX18 Antibody (aa485-514) - LS-C159053 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SNX18 Antibody western blot of WiDr cell line lysates (35 ug/lane). The SNX18 antibody detected the SNX18 protein (arrow).

SNX18 Antibody - NBP2-20443 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SNX18 Antibody [NBP2-20443] - Sample (30 ug of whole cell lysate) A: C8D30 7. 5% SDS PAGE gel, diluted at 1:10000.

SNX18 Antibody - NBP1-82361 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SNX18 Antibody - NBP1-33089 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SNX18 Antibody [NBP1-33089] - Sample (30 ug of whole cell lysate) A: H1299 B: Hela 7.5% SDS PAGE; antibody diluted at 1:1000.

SNX18 Antibody - NBP2-20444 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SNX18 Antibody [NBP2-20444] - Sample (30 ug of whole cell lysate) A: Hela 7. 5% SDS PAGE gel, diluted at 1:1000.

Anti-SNX18 antibody produced in rabbit - HPA037800 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SNX18: <B>Cat. No. HPA037800</B>: Immunohistochemical staining of human urinary bladder shows strong cytoplasmic positivity in urothelial cells.

Anti-SNX18 (206-220) antibody produced in rabbit - SAB1104116 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human SNX18 was separated on SDS-PAGE, blotted with Anti-SNX18 (206-220) (<B>Cat. No. SAB1104116</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000
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