| Gene Symbol |
SNX18
|
| Entrez Gene |
112574
|
| Alt Symbol |
SH3PX2, SH3PXD3B, SNAG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sorting nexin 18
|
| Other Description |
SH3 and PX domain-containing protein 3B|sorting nexin associated golgi protein 1|sorting nexin-18|sorting nexin-associated Golgi protein 1
|
| Swissprots |
Q0VG02 Q05BB3 B4E2B3 Q96RF0 H7BXX3
|
| Accessions |
EAW54894 Q96RF0 AF395536 AAK82415 AI335241 AI669182 AK022059 AK057122 AK304195 BAG65075 BC060791 AAH60791 BC067860 AAH67860 BC117218 AAI17219 BC117220 AAI17221 BJ990551 BJ990552 CD722181 CN360136 CN479485 NM_001102575 NP_001096045 NM_001145427 NP_001138899 NM_052870 NP_443102
|
| Function |
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane. {ECO:0000269|PubMed:18411244, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}.
|
| Subcellular Location |
Endomembrane system; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Partially colocalized with clathrin and dynamin at the cell membrane. Transiently recruited to clathrin- coated pits at a late stage of clathrin-coated vesicle formation.
|