Gene Symbol | SULT2B1 |
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Entrez Gene | 6820 |
Alt Symbol | HSST2 |
Species | Human |
Gene Type | protein-coding |
Description | sulfotransferase family, cytosolic, 2B, member 1 |
Other Description | ST2B1|alcohol sulfotransferase|hydroxysteroid sulfotransferase 2|sulfotransferase 2B1|sulfotransferase family cytosolic 2B member 1 |
Swissprots | O00204 O75814 O00205 |
Accessions | AAC78553 AAC78554 EAW52354 EAW52355 O00204 AK096418 BC034694 AAH34694 HQ447837 ADQ32321 U92314 AAC78498 U92315 AAC78499 XM_005259182 XP_005259239 NM_004605 NP_004596 NM_177973 NP_814444 |
Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. {ECO:0000269|PubMed:12145317, ECO:0000269|PubMed:9799594}. |
Subcellular Location | Cytoplasm. Microsome. Nucleus. Note=Phosphorylation of Ser-348 is required for translocation to the nucleus. |
Tissue Specificity | Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung. {ECO:0000269|PubMed:9799594}. |
Top Pathways | Steroid hormone biosynthesis |
Human SULT2B1 full length protein - ab93936 from Abcam
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Human SULT2B1 full length protein - ab117696 from Abcam
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Human SULT2B1 protein fragment - ab173038 from Abcam
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SULT2B1 Antibody Blocking Peptide - LS-E18411 from LifeSpan Bioscience
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SULT2B1 Antibody Blocking Peptide - LS-E17585 from LifeSpan Bioscience
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SULT2B1 Antibody Blocking Peptide - LS-E17584 from LifeSpan Bioscience
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SULT2B1 Antibody Blocking Peptide - LS-E7006 from LifeSpan Bioscience
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Cytosolic Sulfotransferase 2B1/SULT2B1 Recombinant Protein - H00006820-P01 from Novus Biologicals
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Cytosolic Sulfotransferase 2B1/SULT2B1 Partial Recombinant Protein - H00006820-Q01 from Novus Biologicals
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Recombinant Human Cytosolic Sulfotransferase 2B1/SULT2B1 Protein - NBP1-41135 from Novus Biologicals
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SULT2B1ab-Antibody-N-term-Blocking-peptide - BP2604a from Abgent, a WuXi AppTec company
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Recombinant Human SULT2B1, CF - 6174-ST-020 from R&D Systems
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SULT2B1 Protein (OPPA02374) - OPPA02374 from Aviva Systems Biology
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Human SULT2B1 protein - orb163437 from Biorbyt
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Human SULT2B1 protein - orb90273 from Biorbyt
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Human SULT2B1 His tag protein - orb83863 from Biorbyt
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SULT2B1 Blocking Peptide - 33R-6902 from Fitzgerald
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SULT2B1 Blocking Peptide - 33R-10242 from Fitzgerald
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SULT2B1 Blocking Peptide - 33R-5757 from Fitzgerald
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SULT2B1 protein - 30R-1510 from Fitzgerald
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SULT2B1 (1-365) - AR09409PU-L from Acris Antibodies
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SULT2B1 (1-365) - AR09409PU-N from Acris Antibodies
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SULT2B1 - H00006820-P01-10 from Acris Antibodies
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SULT2B1 - H00006820-P01-25 from Acris Antibodies
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SULT2B1 - H00006820-Q01-10 from Acris Antibodies
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