| Gene Symbol |
PTHLH
|
| Entrez Gene |
286767
|
| Alt Symbol |
PTHrP
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
parathyroid hormone-like hormone
|
| Other Description |
PTH-rP|parathyroid hormone-related protein
|
| Swissprots |
Q8HYS1 P58073 A6QPN9
|
| Accessions |
DAA29452 P58073 AB097837 BAC44840 BC149411 AAI49412 XM_005206914 XP_005206971 XM_010805380 XP_010803682 XM_010805381 XP_010803683 NM_174753 NP_777178
|
| Function |
Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Secreted {ECO:0000250}.
|
| Tissue Specificity |
Expressed in the mammary gland.
|
