| Gene Symbol |
QKI
|
| Entrez Gene |
9444
|
| Alt Symbol |
Hqk, QK, QK1, QK3, hqkI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
QKI, KH domain containing, RNA binding
|
| Other Description |
RNA binding protein HQK|homolog of mouse quaking QKI (KH domain RNA binding protein)|protein quaking|quaking homolog, KH domain RNA binding
|
| Swissprots |
Q9P0X8 Q96KA3 Q96PU6 Q9P0X9 Q96EJ3 Q96PU7 Q969L9 Q9P0Y0 Q9P0X6 Q2I375 Q5MJQ1 Q96PU8 Q9P0X7 Q9P0Y1
|
| Accessions |
BAB69681 EAW47554 EAW47555 EAW47556 EAW47557 EAW47558 EAW47559 EAW47560 Q96PU8 AB067798 BAB69496 AB067799 BAB69497 AB067800 BAB69498 AB067801 BAB69499 AF142422 AAF63417 AF272349 AAL36980 AI146598 AJ420502 AK027309 BAB55032 AK055085 AK096701 AK295235 BAG58228 AK308784 AL050218 AW022136 AW131362 AY780788 AAV98358 BC008190 BC012222 AAH12222 BC019917 AAH19917 DQ323998 ABC88600 EU832828 ACE87839 GQ129383 ACT64517 HQ447847 ADQ32331 XM_011536258 XP_011534560 XM_011536259 XP_011534561 XM_011536260 XP_011534562 XM_011536261 XP_011534563 XR_245557 XR_942633 NM_001301085 NP_001288014 NM_006775 NP_006766 NM_206853 NP_996735 NM_206854 NP_996736 NM_206855 NP_996737
|
| Function |
RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients. {ECO:0000269|PubMed:16342280}.
|
