QKI

Gene Symbol	QKI
Entrez Gene	9444
Alt Symbol	Hqk, QK, QK1, QK3, hqkI
Species	Human
Gene Type	protein-coding
Description	QKI, KH domain containing, RNA binding
Other Description	RNA binding protein HQK|homolog of mouse quaking QKI (KH domain RNA binding protein)|protein quaking|quaking homolog, KH domain RNA binding
Swissprots	Q9P0X8 Q96KA3 Q96PU6 Q9P0X9 Q96EJ3 Q96PU7 Q969L9 Q9P0Y0 Q9P0X6 Q2I375 Q5MJQ1 Q96PU8 Q9P0X7 Q9P0Y1
Accessions	BAB69681 EAW47554 EAW47555 EAW47556 EAW47557 EAW47558 EAW47559 EAW47560 Q96PU8 AB067798 BAB69496 AB067799 BAB69497 AB067800 BAB69498 AB067801 BAB69499 AF142422 AAF63417 AF272349 AAL36980 AI146598 AJ420502 AK027309 BAB55032 AK055085 AK096701 AK295235 BAG58228 AK308784 AL050218 AW022136 AW131362 AY780788 AAV98358 BC008190 BC012222 AAH12222 BC019917 AAH19917 DQ323998 ABC88600 EU832828 ACE87839 GQ129383 ACT64517 HQ447847 ADQ32331 XM_011536258 XP_011534560 XM_011536259 XP_011534561 XM_011536260 XP_011534562 XM_011536261 XP_011534563 XR_245557 XR_942633 NM_001301085 NP_001288014 NM_006775 NP_006766 NM_206853 NP_996735 NM_206854 NP_996736 NM_206855 NP_996737
Function	RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Tissue Specificity	Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients. {ECO:0000269|PubMed:16342280}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human QK1 full length protein - ab171504 from Abcam Category Protein Source E. coli Species Human

Human QK1 full length protein - ab152988 from Abcam Category Protein Source Wheat germ Species Human

QKI Antibody Blocking Peptide - LS-E26166 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

QKI Antibody Blocking Peptide - LS-E23298 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

QKI Antibody Blocking Peptide - LS-E7017 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human QKI/Quaking Protein - H00009444-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human QKI/Quaking Protein - NBP2-23390 from Novus Biologicals Category Protein Prices $269.00 Sizes 50 µg Source E.coli Species Human

QKI/Quaking Peptide - P1190 from Novus Biologicals Category Peptide Species Human

QKI-Antibody-N-term-Blocking-Peptide - BP2707a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

QKI blocking peptide - GTX89271-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

QKI protein (His tag) - 80R-3510 from Fitzgerald Category Protein Prices $275.00 Sizes 50 µg Source E.coli

QK1 Peptide - AC21-0996-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

QKI / Protein quaking (1-341, His-tag) - AR51200PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

QKI / Protein quaking (1-341, His-tag) - AR51200PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

QKI / Protein quaking - H00009444-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

QKI, 1-341aa, Human, His tag, E.coli - 01-P2377 from ARP American Research Products Category Protein Prices $149.00, $369.00, $849.00 Sizes 10 µg, 50 µg, 250 µg Species Human

Quaking Peptide - 46-256P from ProSci Category Peptide Species Mouse

QKI fusion protein - Ag3822 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human QKI, GST-tagged - QKI-2091H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human QKI, KH domain containing, RNA binding, His-tagged - QKI-294H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Protein quaking(QKI) - CSB-YP842739HU CSB-EP842739HU CSB-BP842739HU CSB-MP842739HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

QKI, 1-341aa, Human, His tag, E.coli - ATGP2377 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 10 µg, 50 µg, 250 µg Species Human

QKI Protein (Recombinant) - abx262885 from Abbexa Category Protein

QKI / Protein quaking (transcript variant 1) - TP305779 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

QKI / Protein quaking (transcript variant 3) - TP315734 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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