PTPN13

Gene Symbol PTPN13
Entrez Gene 5783
Alt Symbol FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE, hPTP1E
Species Human
Gene Type protein-coding
Description protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
Other Description fas-associated protein-tyrosine phosphatase 1|hPTPE1|protein-tyrosine phosphatase 1E|protein-tyrosine phosphatase PTPL1|tyrosine-protein phosphatase non-receptor type 13
Swissprots Q9UDA8 Q15264 Q8IWH7 Q15263 Q9NYN9 Q12923 Q15674 Q16826 Q15159 B2RTR0 Q15265
Accessions AAY40972 CCA94573 EAX05965 EAX05966 EAX05967 EAX05968 Q12923 AB208904 BAD92141 AF233323 AAF63474 AK056151 BC039610 AAH39610 BC139915 BC140777 AAI40778 BC144520 BG202767 BX647553 CAH10380 D21209 BAA04750 D21210 BAA04751 D21211 BAA04752 DA625835 L34583 AAC41755 U12128 AAB60339 U12129 U12130 U12131 U12132 X79676 CAA56124 X80289 CAA56563 XM_005263167 XP_005263224 XM_011532163 XP_011530465 XM_011532164 XP_011530466 XM_011532165 XP_011530467 XM_011532166 XP_011530468 XM_011532167 XP_011530469 XM_011532168 XP_011530470 XM_011532169 XP_011530471 XM_011532170 XP_011530472 XM_011532171 XP_011530473 XM_011532172 XP_011530474 NM_006264 NP_006255 NM_080683 NP_542414 NM_080684 NP_542415 NM_080685 NP_542416
Function Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000269|PubMed:11356191}. Cell projection, lamellipodium {ECO:0000269|PubMed:11356191}. Note=Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover.
Tissue Specificity Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain.

Fap-1 (H-300) - sc-15356 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Fap-1 (H-300): sc-15356. Western blot analysis of Fap-1 expression in SW480 whole cell lysate.

Fap-1 (C-20) - sc-1138 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Fap-1 (C-20): sc-1138. Immunoperoxidase staining of formalin fixed, paraffin-embedded human fallopian tube tissue showing cytoplasmic staining of glandular cells.

Fap-1 (L-20) - sc-1729 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PTPN13 antibody - ab198882 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue labeling PTPN13 with ab198882 at 1/30 dilution.

Anti-PTPN13 antibody [AC21] - ab49446 from Abcam

Prices $359.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone AC21
Immunohistochemical staining (Paraffin section) for PTPN13 (Fas-associated phosphatase 1) using ab49446 with normal Human thyroid as positive control. Note intense cytoplasmic staining of thyroid epithelial cells.

Anti-PTPN13 antibody - C-terminal - ab189881 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain, cerebellum tissue, labeling PTPN13 with ab189881 at 5 µg/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-FAP-1 / PTPN13 Antibody (aa1279-1883) - LS-C23434 from LifeSpan Bioscience

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-FAP-1 / PTPN13 Antibody (aa1279-1883) - LS-C65840 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-FAP-1 / PTPN13 Antibody (aa1760-1775) - LS-C148269 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-FAP-1 / PTPN13 Antibody (aa2290-2491) - LS-C188997 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-FAP-1 / PTPN13 Antibody (aa2451-2466) IHC-plus™ - LS-B862 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PTPN13 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B862 concentration 5 ug/ml.

Anti-FAP Alpha Antibody (Lys366) - LS-C176018 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of FAP-1 (K366) pAb in paraffin-embedded human breast carcinoma tissue.

Anti-FAP-1 / PTPN13 Antibody (aa1279-1883) - LS-C148268 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of FAP-1 in formalin-fixed, paraffin embedded ovarian carcinoma cores from a tissue microarray using LS-C148268 at 1:2000. A-D, samples are from four different patients. A1-D1 are high magnification images from A-D, respectively. Hematoxylin-Eosin counterstain.

Anti-FAP-1 / PTPN13 Antibody (aa2290-2491) IHC-plus™ - LS-B3310 from LifeSpan Bioscience

Prices $395.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
Anti-PTPN13 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3310 concentration 10 ug/ml.

PTPN13/PTPL1 Antibody - NB100-56139 from Novus Biologicals

Prices $129.00, $279.00
Sizes 25 µl, 50 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PTPN13/PTPL1 Antibody [NB100-56139] - Analysis of PTPN13/PTPL1 using this antibody. In ovarian carcinoma cell lines PTPN13/PTPL1 expression was detected in SK-OV-3 and OVCAR-3, but not in BG-1 or HEY. Human Jurkat T and 293 kidney cell lines were used as negative and positive controls, respectively.

PTPN13/PTPL1 Antibody - NB100-56140 from Novus Biologicals

Prices $129.00, $199.00
Sizes 25 µl, 50 µl
Host Rabbit
Clonality Polyclonal

PTPN13/PTPL1 Antibody (359313) - MAB3577 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 359313

PTPN13/PTPL1 Antibody [Unconjugated] - AF3577 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Human PTPN13/PTPL1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3577) followed by HRP-conjugated Anti‑Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for PTPN13/PTPL1 at approximately 260 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

PTPN13/PTPL1 Antibody - NBP1-02579 from Novus Biologicals

Prices $329.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

PTPN13/PTPL1 Antibody - H00005783-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

FAP1 Polyclonal Antibody - bs-5760R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PTPN13 antibody produced in chicken - GW21551 from Sigma-Aldrich

Host Chicken
Clonality Polyclonal

Anti-PTPN13 antibody produced in chicken - GW21497A from Sigma-Aldrich

Prices $267.50
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Human PTPN13/PTPL1 Antibody - MAB3577 from R&D Systems

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clone 359313
Detection of Human PTPN13/PTPL1 by Western Blot. Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Human PTPN13/PTPL1 Monoclonal Antibody (Catalog # MAB3577) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007 ). A specific band was detected for PTPN13/PTPL1 at approximately 260 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 4 .

Human PTPN13/PTPL1 MAb (Clone 359313), Mouse IgG2B - MAB3577-SP from R&D Systems

Host Mouse
Clonality Monoclonal
Clone 359313
Detection of Human PTPN13/PTPL1 by Western Blot. Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Human PTPN13/PTPL1 Monoclonal Antibody (Catalog # MAB3577) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for PTPN13/PTPL1 at approximately 260 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 4.
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