PTPN13
| Gene Symbol | PTPN13 |
|---|---|
| Entrez Gene | 5783 |
| Alt Symbol | FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE, hPTP1E |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) |
| Other Description | fas-associated protein-tyrosine phosphatase 1|hPTPE1|protein-tyrosine phosphatase 1E|protein-tyrosine phosphatase PTPL1|tyrosine-protein phosphatase non-receptor type 13 |
| Swissprots | Q9UDA8 Q15264 Q8IWH7 Q15263 Q9NYN9 Q12923 Q15674 Q16826 Q15159 B2RTR0 Q15265 |
| Accessions | AAY40972 CCA94573 EAX05965 EAX05966 EAX05967 EAX05968 Q12923 AB208904 BAD92141 AF233323 AAF63474 AK056151 BC039610 AAH39610 BC139915 BC140777 AAI40778 BC144520 BG202767 BX647553 CAH10380 D21209 BAA04750 D21210 BAA04751 D21211 BAA04752 DA625835 L34583 AAC41755 U12128 AAB60339 U12129 U12130 U12131 U12132 X79676 CAA56124 X80289 CAA56563 XM_005263167 XP_005263224 XM_011532163 XP_011530465 XM_011532164 XP_011530466 XM_011532165 XP_011530467 XM_011532166 XP_011530468 XM_011532167 XP_011530469 XM_011532168 XP_011530470 XM_011532169 XP_011530471 XM_011532170 XP_011530472 XM_011532171 XP_011530473 XM_011532172 XP_011530474 NM_006264 NP_006255 NM_080683 NP_542414 NM_080684 NP_542415 NM_080685 NP_542416 |
| Function | Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). {ECO:0000269|PubMed:15611135, ECO:0000269|PubMed:23604317}. |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000269|PubMed:11356191}. Cell projection, lamellipodium {ECO:0000269|PubMed:11356191}. Note=Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover. |
| Tissue Specificity | Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain. |
Fap-1 CRISPR/Cas9 KO Plasmid (h) - sc-401758 from Santa Cruz Biotechnology
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Fap-1 HDR Plasmid (h) - sc-401758-HDR from Santa Cruz Biotechnology
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Fap-1 Double Nickase Plasmid (h) - sc-401758-NIC from Santa Cruz Biotechnology
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Fap-1 Double Nickase Plasmid (h2) - sc-401758-NIC-2 from Santa Cruz Biotechnology
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Fap-1 CRISPR Activation Plasmid (h) - sc-401758-ACT from Santa Cruz Biotechnology
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Fap-1 CRISPR Activation Plasmid (h2) - sc-401758-ACT-2 from Santa Cruz Biotechnology
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Fap-1 Lentiviral Activation Particles (h) - sc-401758-LAC from Santa Cruz Biotechnology
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Fap-1 Lentiviral Activation Particles (h2) - sc-401758-LAC-2 from Santa Cruz Biotechnology
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Fap-1 siRNA (h) - sc-43560 from Santa Cruz Biotechnology
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Fap-1 shRNA Plasmid (h) - sc-43560-SH from Santa Cruz Biotechnology
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Fap-1 shRNA (h) Lentiviral Particles - sc-43560-V from Santa Cruz Biotechnology
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PTPN13/PTPL1 RNAi - H00005783-R02 from Novus Biologicals
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PTPN13/PTPL1 RNAi - H00005783-R03 from Novus Biologicals
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PTPN13/PTPL1 RNAi - H00005783-R04 from Novus Biologicals
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PTPN13/PTPL1 RNAi - H00005783-R01 from Novus Biologicals
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MISSION® esiRNA - EHU146051 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0735 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0734 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0733 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2336 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2336 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05068 from Sigma-Aldrich
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PTPN13 siRNA (Human) - CRH3906 from Cohesion Biosciences
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shRNA set against Human PTPN13 (NM_006264.2) - SHH386456 from Creative biogene
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Human PTPN13 siRNA - orb264408 from Biorbyt
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