Gene Symbol | STXBP3 |
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Entrez Gene | 6814 |
Alt Symbol | MUNC18-3, MUNC18C, PSP, UNC-18C |
Species | Human |
Gene Type | protein-coding |
Description | syntaxin binding protein 3 |
Other Description | platelet Sec1 protein|protein unc-18 homolog 3|protein unc-18 homolog C|syntaxin 4 binding protein|syntaxin-binding protein 3|unc18-3 |
Swissprots | Q9UPD7 A8K5K7 O00186 Q86YJ3 Q53FW1 A8K269 |
Accessions | EAW56330 EAW56331 EAW56332 O00186 AF032922 AAC69606 AK223170 BAD96890 AK290134 BAF82823 AK291322 BAF84011 AK312910 BAG35756 BC028028 BC038099 AAH38099 BC047764 AAH47764 CN409056 D63506 BAA19482 NM_007269 NP_009200 |
Function | Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:10194441}. Cell membrane {ECO:0000269|PubMed:10194441}. Note=In platelets, predominantly cytosolic. Low amounts membrane-associated. |
Tissue Specificity | Megakaryocytes and platelets. |
Unc18-3 CRISPR/Cas9 KO Plasmid (h) - sc-405304 from Santa Cruz Biotechnology
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Unc18-3 HDR Plasmid (h) - sc-405304-HDR from Santa Cruz Biotechnology
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Unc18-3 Double Nickase Plasmid (h) - sc-405304-NIC from Santa Cruz Biotechnology
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Unc18-3 Double Nickase Plasmid (h2) - sc-405304-NIC-2 from Santa Cruz Biotechnology
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Unc18-3 CRISPR Activation Plasmid (h) - sc-405304-ACT from Santa Cruz Biotechnology
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Unc18-3 CRISPR Activation Plasmid (h2) - sc-405304-ACT-2 from Santa Cruz Biotechnology
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Unc18-3 Lentiviral Activation Particles (h) - sc-405304-LAC from Santa Cruz Biotechnology
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Unc18-3 Lentiviral Activation Particles (h2) - sc-405304-LAC-2 from Santa Cruz Biotechnology
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Unc18-3 siRNA (h) - sc-42312 from Santa Cruz Biotechnology
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Unc18-3 shRNA Plasmid (h) - sc-42312-SH from Santa Cruz Biotechnology
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Unc18-3 shRNA (h) Lentiviral Particles - sc-42312-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU033611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20793 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20793 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05698 from Sigma-Aldrich
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STXBP3 siRNA (Human) - CRH4659 from Cohesion Biosciences
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STXBP3 - MBS8225539 from MyBioSource
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shRNA set against Human STXBP3 (NM_007269.2) - SHH420456 from Creative biogene
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STXBP3 shRNA Plasmid (Human) - CHH4659 from Cohesion Biosciences
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STXBP3 miRNA 3'UTR clone - MiUTR3H-09928 from Creative biogene
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