JMJD6

Gene Symbol JMJD6
Entrez Gene 23210
Alt Symbol PSR, PTDSR, PTDSR1
Species Human
Gene Type protein-coding
Description jumonji domain containing 6
Other Description bifunctional arginine demethylase and lysyl-hydroxylase JMJD6|histone arginine demethylase JMJD6|jmjC domain-containing protein 6|jumonji domain-containing protein 6|lysyl-hydroxylase JMJD6|peptide-lysine 5-dioxygenase JMJD6|phosphatidylserine receptor
Swissprots Q8IUM5 B3KMN8 Q6NYC1 Q86VY0 B4DGX1 Q9Y4E2
Accessions EAW89429 EAW89430 EAW89431 EAW89432 EAW89433 EAW89434 Q6NYC1 AA226560 AA775442 AB011157 BAA25511 AB073711 BAC16755 AK021780 BAG51050 AK294816 BAG57932 AK314541 BC016837 BC047003 AAH47003 BC066654 AAH66654 DB451815 EF527406 ABU68576 EF527407 ABU68577 XR_934428 XR_934429 NM_001081461 NP_001074930 NM_015167 NP_055982
Function Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splici
Subcellular Location Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle.
Tissue Specificity Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells. {ECO:0000269|PubMed:15072554, ECO:0000269|PubMed:15622002, ECO:0000269|PubMed:9628581}.

PSR (C-1) - sc-48405 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PSR (C-1): sc-48405. Western blot analysis of PSR expression in Caki-1 (A), THP-1 (B), HT-1080 (C), HeLa (D), A549 (E), U-937 (F) and PMA induced U-937 (G) whole cell lysates.

PSR (D-4) - sc-28349 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PSR (D-4): sc-28349. Western blot analysis of PSR expression in Caki-1 (A), THP-1 (B), HT-1080 (C), HeLa (D), A549 (E), NIH/3T3 (F) and 3611-RF (G) whole cell lysates.

PSR (L-20) - sc-11633 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PSR (L-20): sc-11633. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human prostate tissue showing membrane staining.

PSR (H-7) - sc-28348 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PSR (H-7): sc-28348. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing nuclear staining of cells in ductus seminiferus and Leydig cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

PSR (APSR-14.4) - sc-32740 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Hamster
Clonality Monoclonal
PSR (APSR-14.4) PE: sc-32740 PE. Intracellular FCM analysis of fixed and permeabilized A549 cells. Black line histogram represents the isotype control, normal Armenian hamster IgG: sc-2875.

PSR (H-300) - sc-11366 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PSR (H-300): sc-11366. Western blot analysis of PSR expression in Caki-1 (A), THP-1 (B), HT-1080 (C), HeLa (D), A549 (E), NIH/3T3 (F) and 3611-RF (G) whole cell lysates.

PSR (C-18) - sc-11635 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PSR (N-20) - sc-11632 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PSR (N-20): sc-11632. Western blot analysis of PSR expression in Caki-1 (A), THP-1 (B), HT-1080 (C), HeLa (D), A549 (E) and NIH/3T3 (F) whole cell lysates.

Anti-JMJD6 antibody - ab64575 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-JMJD6 antibody (ab64575) at 1 µg/mlLane 1 : Liver (Rat) Tissue LysateLane 2 : Liver (Mouse) Tissue Lysate Lane 3 : Heart (Mouse) Tissue Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-JMJD6 antibody - ab65770 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-JMJD6 antibody (ab65770) at 1/1000 dilution + Nuclear extracts of HeLa cells

Anti-JMJD6 antibody - ab176172 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-JMJD6 antibody (ab176172) at 1 µg/mlLane 1 : Human brain lysateLane 2 : Human brain lysate with With Immunizing peptideLane 3 : Mouse brain lysate

Anti-JMJD6 antibody [5B4] - ab154988 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5B4

Anti-JMJD6 antibody - N-terminal - ab135066 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-JMJD6 antibody - N-terminal (ab135066) at 1/1000 dilutionLane 1 : MEF lysateLane 2 : 293T lysate

Anti-JMJD6 / PSR Antibody (aa214-263) IHC-plus™ - LS-B8042 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-JMJD6 / PSR antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8042 dilution 5-7.5 ug/ml.

Anti-JMJD6 / PSR Antibody (aa127-144) IHC-plus™ - LS-B7234 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-JMJD6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7234 concentration 10 ug/ml.

Anti-JMJD6 / PSR Antibody (aa178-195) - LS-C149006 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-JMJD6 / PSR Antibody (aa284-311, AP) - LS-C260699 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-JMJD6 / PSR Antibody (aa284-311, APC) - LS-C260700 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-JMJD6 / PSR Antibody (aa296-345) - LS-C30891 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Fetal Thymus Lysate

Anti-JMJD6 / PSR Antibody (aa284-311, Biotin) - LS-C260701 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-JMJD6 / PSR Antibody (aa284-311, FITC) - LS-C260702 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-JMJD6 / PSR Antibody (aa284-311, Azide-free, HRP) - LS-C260703 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-JMJD6 / PSR Antibody (aa284-311, PE) - LS-C260704 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-JMJD6 / PSR Antibody (N-Terminus, AP) - LS-C278637 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-JMJD6 / PSR Antibody (N-Terminus) - LS-C101734 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
JMJD6 antibody LS-C101734 Western blot of HeLa lysate.
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