| Gene Symbol |
JMJD6
|
| Entrez Gene |
23210
|
| Alt Symbol |
PSR, PTDSR, PTDSR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
jumonji domain containing 6
|
| Other Description |
bifunctional arginine demethylase and lysyl-hydroxylase JMJD6|histone arginine demethylase JMJD6|jmjC domain-containing protein 6|jumonji domain-containing protein 6|lysyl-hydroxylase JMJD6|peptide-lysine 5-dioxygenase JMJD6|phosphatidylserine receptor
|
| Swissprots |
Q8IUM5 B3KMN8 Q6NYC1 Q86VY0 B4DGX1 Q9Y4E2
|
| Accessions |
EAW89429 EAW89430 EAW89431 EAW89432 EAW89433 EAW89434 Q6NYC1 AA226560 AA775442 AB011157 BAA25511 AB073711 BAC16755 AK021780 BAG51050 AK294816 BAG57932 AK314541 BC016837 BC047003 AAH47003 BC066654 AAH66654 DB451815 EF527406 ABU68576 EF527407 ABU68577 XR_934428 XR_934429 NM_001081461 NP_001074930 NM_015167 NP_055982
|
| Function |
Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splici
|
| Subcellular Location |
Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle.
|
| Tissue Specificity |
Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells. {ECO:0000269|PubMed:15072554, ECO:0000269|PubMed:15622002, ECO:0000269|PubMed:9628581}.
|
![Western Blot: JMJD6 Overexpression Lysate (Adult Normal) [NBL1-12107] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for JMJD6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5847_JMJD6%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12107-img0002.jpg)
![Western Blot: JMJD6 Overexpression Lysate (Adult Normal) [NBP2-08420] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for JMJD6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4282_JMJD6%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-08420-img0001.jpg)