JMJD6

Gene Symbol	JMJD6
Entrez Gene	23210
Alt Symbol	PSR, PTDSR, PTDSR1
Species	Human
Gene Type	protein-coding
Description	jumonji domain containing 6
Other Description	bifunctional arginine demethylase and lysyl-hydroxylase JMJD6|histone arginine demethylase JMJD6|jmjC domain-containing protein 6|jumonji domain-containing protein 6|lysyl-hydroxylase JMJD6|peptide-lysine 5-dioxygenase JMJD6|phosphatidylserine receptor
Swissprots	Q8IUM5 B3KMN8 Q6NYC1 Q86VY0 B4DGX1 Q9Y4E2
Accessions	EAW89429 EAW89430 EAW89431 EAW89432 EAW89433 EAW89434 Q6NYC1 AA226560 AA775442 AB011157 BAA25511 AB073711 BAC16755 AK021780 BAG51050 AK294816 BAG57932 AK314541 BC016837 BC047003 AAH47003 BC066654 AAH66654 DB451815 EF527406 ABU68576 EF527407 ABU68577 XR_934428 XR_934429 NM_001081461 NP_001074930 NM_015167 NP_055982
Function	Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splici
Subcellular Location	Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle.
Tissue Specificity	Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells. {ECO:0000269|PubMed:15072554, ECO:0000269|PubMed:15622002, ECO:0000269|PubMed:9628581}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human JMJD6 full length protein - ab132042 from Abcam Category Protein Source Wheat germ Species Human

Human JMJD6 full length protein - ab196071 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human JMJD6 full length protein - ab202239 from Abcam Category Protein Source E. coli Species Human

Human JMJD6 peptide - ab64574 from Abcam Category Peptide

Human JMJD6 protein fragment - ab153208 from Abcam Category Protein Source Wheat germ Species Human

Human JMJD6 protein fragment - ab176947 from Abcam Category Protein Source E. coli Species Human

JMJD6 peptide - ab110802 from Abcam Category Peptide

JMJD6 / PSR Antibody Blocking Peptide - LS-E3029 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

JMJD6 / PSR Antibody Blocking Peptide - LS-E14129 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

JMJD6 / PSR Antibody Blocking Peptide - LS-E14130 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

JMJD6 / PSR Antibody Blocking Peptide - LS-E30770 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

JMJD6 / PSR Antibody Blocking Peptide - LS-E11096 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

JMJD6/PSR Partial Recombinant Protein - H00023210-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

JMJD6/PSR Recombinant Protein - H00023210-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

JMJD6/PSR Blocking Peptide - NBP1-77075PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

JMJD6-Antibody-C-term-Blocking-peptide - BP14160b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

JMJD6 Blocking Peptide - 33R-6716 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

JMJD6 protein (His tag) - 80R-4133 from Fitzgerald Category Protein Prices $375.00 Sizes 50 µg Source E.coli

PTDSR Blocking Peptide - 33R-9907 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PTDSR Blocking Peptide - 33R-7320 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

JMJD6 / PTDSR (1-414, His-tag) - AR51819PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

JMJD6 / PTDSR (1-414, His-tag) - AR51819PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

JMJD6 / PTDSR - H00023210-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

JMJD6 / PTDSR - H00023210-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

JMJD6 / PTDSR - H00023210-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

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