| Gene Symbol |
CLEC4D
|
| Entrez Gene |
338339
|
| Alt Symbol |
CLEC-6, CLEC6, CLECSF8, MCL, MPCL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
C-type lectin domain family 4, member D
|
| Other Description |
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 8|C-type lectin domain family 4 member D|C-type lectin receptor|C-type lectin superfamily member 8|C-type lectin-like receptor 6|macrophage C-type lectin
|
| Swissprots |
Q8WXI8 Q8N5J5
|
| Accessions |
EAW88619 Q8WXI8 AF411850 AAL37713 AK314071 AY115592 AAM75389 AY297446 AAQ63173 AY486482 AAS59161 AY486483 AAS59162 BC032313 AAH32313 BI909298 DQ894429 ABM85355 XM_011520632 XP_011518934 XM_011520633 XP_011518935 NM_080387 NP_525126
|
| Function |
Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells. {ECO:0000269|PubMed:14971047}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma. {ECO:0000269|PubMed:14971047}.
|
![Western Blot: CLEC4D Overexpression Lysate (Adult Normal) [NBL1-09260] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CLEC4D.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6085_CLEC4D%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09260-img0002.jpg)