Gene Symbol | CLEC4D |
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Entrez Gene | 338339 |
Alt Symbol | CLEC-6, CLEC6, CLECSF8, MCL, MPCL |
Species | Human |
Gene Type | protein-coding |
Description | C-type lectin domain family 4, member D |
Other Description | C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 8|C-type lectin domain family 4 member D|C-type lectin receptor|C-type lectin superfamily member 8|C-type lectin-like receptor 6|macrophage C-type lectin |
Swissprots | Q8WXI8 Q8N5J5 |
Accessions | EAW88619 Q8WXI8 AF411850 AAL37713 AK314071 AY115592 AAM75389 AY297446 AAQ63173 AY486482 AAS59161 AY486483 AAS59162 BC032313 AAH32313 BI909298 DQ894429 ABM85355 XM_011520632 XP_011518934 XM_011520633 XP_011518935 NM_080387 NP_525126 |
Function | Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells. {ECO:0000269|PubMed:14971047}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
Tissue Specificity | Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma. {ECO:0000269|PubMed:14971047}. |
CLEC-6 CRISPR/Cas9 KO Plasmid (h) - sc-416830 from Santa Cruz Biotechnology
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CLEC-6 HDR Plasmid (h) - sc-416830-HDR from Santa Cruz Biotechnology
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CLEC-6 Double Nickase Plasmid (h) - sc-416830-NIC from Santa Cruz Biotechnology
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CLEC-6 Double Nickase Plasmid (h2) - sc-416830-NIC-2 from Santa Cruz Biotechnology
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CLEC-6 CRISPR Activation Plasmid (h) - sc-416830-ACT from Santa Cruz Biotechnology
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CLEC-6 CRISPR Activation Plasmid (h2) - sc-416830-ACT-2 from Santa Cruz Biotechnology
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CLEC-6 Lentiviral Activation Particles (h) - sc-416830-LAC from Santa Cruz Biotechnology
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CLEC-6 Lentiviral Activation Particles (h2) - sc-416830-LAC-2 from Santa Cruz Biotechnology
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CLEC-6 siRNA (h) - sc-60398 from Santa Cruz Biotechnology
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CLEC-6 shRNA Plasmid (h) - sc-60398-SH from Santa Cruz Biotechnology
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CLEC-6 shRNA (h) Lentiviral Particles - sc-60398-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU136511 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6216 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6216 from Sigma-Aldrich
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CLEC4D siRNA (Human) - CRJ7235 from Cohesion Biosciences
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CLEC4D - MBS8210528 from MyBioSource
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shRNA set against Human CLEC4D (NM_080387.4) - SHH265157 from Creative biogene
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shRNA set against Human CLEC4D(NM_080387.4) - SHG182467 from Creative biogene
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Human CLEC4D siRNA - orb277736 from Biorbyt
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CLEC4D shRNA Plasmid (Human) - CHJ7235 from Cohesion Biosciences
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CLEC4D miRNA 3'UTR clone - MiUTR3H-10927 from Creative biogene
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