| Gene Symbol |
STRADB
|
| Entrez Gene |
55437
|
| Alt Symbol |
ALS2CR2, CALS-21, ILPIP, ILPIPA, PAPK, PRO1038
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
STE20-related kinase adaptor beta
|
| Other Description |
ILP-interacting protein ILPIPA|STE20-related kinase adapter protein beta|STRAD beta|amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2|amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein|pseudokinase ALS2CR2
|
| Swissprots |
Q9C0K7 Q9P1L0 Q5BKY7
|
| Accessions |
AAY14692 CAE92102 EAW70273 EAW70274 EAW70275 EAW70276 Q9C0K7 AB038950 BAB32500 AF116618 AAF71042 AK024720 AK027637 BAB55254 AK290457 BAF83146 AY093697 AAM19143 BC008302 AAH08302 BC090871 AAH90871 BG110753 DQ893688 ABM84614 DQ893689 ABM84615 DQ896519 ABM87518 DQ896865 ABM87864 EU176785 ABW03586 EU176786 ABW03587 W74591 XM_005246669 XP_005246726 NM_001206864 NP_001193793 NM_018571 NP_061041
|
| Function |
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:14517248}. Cytoplasm {ECO:0000269|PubMed:14517248}.
|
| Tissue Specificity |
Highly expressed in heart, skeletal muscle, testis, liver and colon. {ECO:0000269|PubMed:11161814, ECO:0000269|PubMed:12048196}.
|
| Top Pathways |
AMPK signaling pathway
|
![Western Blot: ALS2CR2 Overexpression Lysate (Adult Normal) [NBL1-07490] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ALS2CR2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1943_ALS2CR2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07490-img0002.jpg)