SAMD8

Gene Symbol	SAMD8
Entrez Gene	142891
Alt Symbol	HEL-177, SMSr
Species	Human
Gene Type	protein-coding
Description	sterile alpha motif domain containing 8
Other Description	CPE synthase|SAM domain-containing protein 8|ceramide phosphoethanolamine synthase|epididymis luminal protein 177|sphingomyelin synthase related|sphingomyelin synthase-related protein 1|sterile alpha motif domain-containing protein 8
Swissprots	Q66K52 Q5JSC5 Q5JSC8 Q96LT4
Accessions	EAW54565 EAW54566 EAW54567 EAW54568 Q96LT4 AK057811 BAB71586 BC080593 AAH80593 BC140219 AAI40220 BC146556 AAI46557 EU668332 ACF94485 XM_005269541 XP_005269598 XM_011539311 XP_011537613 XM_011539312 XP_011537614 XM_011539313 XP_011537615 NM_001174156 NP_001167627 NM_144660 NP_653261
Function	Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway. {ECO:0000269|PubMed:19506037}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:19506037}; Multi-pass membrane protein {ECO:0000269|PubMed:19506037}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SAMD8 full length protein - ab165493 from Abcam Category Protein Source Wheat germ Species Human

SAMD8 Antibody Blocking Peptide - LS-E21415 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SAMD8 Protein - H00142891-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SAMD8 Blocking Peptide - 33R-6349 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SAMD8 / SMSr - H00142891-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SAMD8 / SMSr - H00142891-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SAMD8 Protein - NBP2-13280PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

SAMD8 fusion protein - Ag25310 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SAMD8-Blocking-Peptide-N-term - BP12035a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SAMD8 Peptide, Human - M34GP13770H from Creative Peptides Category Peptide Source Synthetic. Species Human

SAMD8 fusion protein - Ag25321 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET30a Species Human

Sphingomyelin synthase-related protein 1 (SAMD8), Recombinant Protein - MBS7029248 from MyBioSource Category Protein Prices $1,220.00, $2,205.00, $3,415.00 Sizes 10 µg, 50 µg, 100 µg Source E Coli Species Human

Sphingomyelin synthase-related protein 1 (SAMD8), Recombinant Protein - MBS7094241 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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