Gene Symbol | SAMD8 |
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Entrez Gene | 142891 |
Alt Symbol | HEL-177, SMSr |
Species | Human |
Gene Type | protein-coding |
Description | sterile alpha motif domain containing 8 |
Other Description | CPE synthase|SAM domain-containing protein 8|ceramide phosphoethanolamine synthase|epididymis luminal protein 177|sphingomyelin synthase related|sphingomyelin synthase-related protein 1|sterile alpha motif domain-containing protein 8 |
Swissprots | Q66K52 Q5JSC5 Q5JSC8 Q96LT4 |
Accessions | EAW54565 EAW54566 EAW54567 EAW54568 Q96LT4 AK057811 BAB71586 BC080593 AAH80593 BC140219 AAI40220 BC146556 AAI46557 EU668332 ACF94485 XM_005269541 XP_005269598 XM_011539311 XP_011537613 XM_011539312 XP_011537614 XM_011539313 XP_011537615 NM_001174156 NP_001167627 NM_144660 NP_653261 |
Function | Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway. {ECO:0000269|PubMed:19506037}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:19506037}; Multi-pass membrane protein {ECO:0000269|PubMed:19506037}. |
SAMD8 (C-12) - sc-139049 from Santa Cruz Biotechnology
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SAMD8 (N-13) - sc-139050 from Santa Cruz Biotechnology
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Anti-SAMD8 antibody - ab84940 from Abcam
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Anti-SAMD8 Antibody (aa38-67, APC) - LS-C240369 from LifeSpan Bioscience
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Anti-SAMD8 Antibody (aa38-67, AP) - LS-C240370 from LifeSpan Bioscience
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Anti-SAMD8 Antibody (aa38-67, Biotin) - LS-C240371 from LifeSpan Bioscience
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Anti-SAMD8 Antibody (aa38-67, FITC) - LS-C240373 from LifeSpan Bioscience
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Anti-SAMD8 Antibody (aa38-67, PE) - LS-C240377 from LifeSpan Bioscience
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Anti-SAMD8 Antibody (aa38-67, Azide-free, HRP) - LS-C248075 from LifeSpan Bioscience
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Anti-SAMD8 Antibody (aa45-75) - LS-C324900 from LifeSpan Bioscience
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Anti-SAMD8 Antibody (aa180-229) - LS-C102794 from LifeSpan Bioscience
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Anti-SAMD8 Antibody (aa38-67) - LS-C162859 from LifeSpan Bioscience
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SAMD8 Antibody - NBP1-60113 from Novus Biologicals
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SAMD8 Antibody - NBP2-13280 from Novus Biologicals
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Anti-SAMD8 antibody produced in rabbit - HPA044402 from Sigma-Aldrich
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Anti-SAMD8 antibody produced in rabbit - SAB2102076 from Sigma-Aldrich
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ANTI-SAMD8 (N-TERM) antibody produced in rabbit - SAB1304183 from Sigma-Aldrich
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SAMD8 antibody - middle region (ARP58524_P050) - ARP58524_P050 from Aviva Systems Biology
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SAMD8-Antibody-N-term - AP12035a from Abgent, a WuXi AppTec company
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SAMD8 Antibody - N-terminal region (OAAB08280) - OAAB08280 from Aviva Systems Biology
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SAMD8 antibody - 70R-7056 from Fitzgerald
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SAMD8 / SMSr antibody - AP05209PU-N from Acris Antibodies
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SAMD8 / SMSr (N-term) antibody - AP53793PU-N from Acris Antibodies
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SAMD8 / SMSr antibody - PAB10381 from Acris Antibodies
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Rabbit Anti-Mouse SAMD8 (N-term) - 102-11364 from RayBiotech
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