CAND1

Gene Symbol	CAND1
Entrez Gene	55832
Alt Symbol	TIP120, TIP120A
Species	Human
Gene Type	protein-coding
Description	cullin-associated and neddylation-dissociated 1
Other Description	TBP interacting protein|TBP-interacting protein 120A|TBP-interacting protein of 120 kDa A|cullin-associated NEDD8-dissociated protein 1|cullin-associated and neddylation-dissociated protein 1|p120 CAND1
Swissprots	Q96JZ9 Q9H0G2 Q9BTC4 Q9P0H7 Q86VP6 Q8NDJ4 O94918 Q9UF85 Q6PIY4 B2RAU3 Q96T19
Accessions	EAW97171 EAW97172 Q86VP6 AB020636 BAA74852 AF157326 AAF67492 AK000976 BAG50842 AK001791 BAG50975 AK027404 BAB55090 AK027783 BAB55365 AK074922 AK096010 AK129780 AK292456 BAF85145 AK314358 BAG36990 AL133560 CAB63714 AL136810 CAB66744 AL833880 CAD38737 BC004232 AAH04232 BC026220 AAH26220 BC050341 AAH50341 BQ024785 DB064887 DB098973 EU832277 ACE87534 EU832362 ACE86847 NM_018448 NP_060918
Function	Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:21249194}. Nucleus {ECO:0000269|PubMed:21249194}. Note=Predominantly cytoplasmic.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CAND1 Gene cDNA clone plasmid - HG11467-M from Sino Biological Species Human

Human CAND1/TIP120A Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11467-ACR from Sino Biological Species Human

Human CAND1/TIP120A Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11467-ANR from Sino Biological Species Human

Human CAND1/TIP120A Gene ORF cDNA clone expression plasmid - HG11467-UT from Sino Biological Species Human

Human CAND1/TIP120A Gene ORF cDNA clone expression plasmid, C-HA tag - HG11467-CY from Sino Biological Species Human

Human CAND1/TIP120A Gene ORF cDNA clone expression plasmid, N-HA tag - HG11467-NY from Sino Biological Species Human

Human CAND1/TIP120A Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11467-ANG from Sino Biological Species Human

Human CAND1/TIP120A Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11467-ACG from Sino Biological Species Human

Human CAND1/TIP120A Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11467-M-F from Sino Biological Species Human

Human CAND1/TIP120A Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11467-NF from Sino Biological Species Human

Human CAND1/TIP120A Gene ORF cDNA clone expression plasmid, C-His tag - HG11467-CH from Sino Biological Species Human

Human CAND1/TIP120A Gene ORF cDNA clone expression plasmid, N-His tag - HG11467-NH from Sino Biological Species Human

Human CAND1/TIP120A Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11467-NM from Sino Biological Species Human

Human CAND1/TIP120A Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11467-CF from Sino Biological Species Human

Human CAND1/TIP120A Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11467-CM from Sino Biological Species Human

Human CAND1 ORF clone(NM_018448.3) - CDCL183036 from Creative biogene Species Human

Search more