CAND1

Gene Symbol	CAND1
Entrez Gene	55832
Alt Symbol	TIP120, TIP120A
Species	Human
Gene Type	protein-coding
Description	cullin-associated and neddylation-dissociated 1
Other Description	TBP interacting protein|TBP-interacting protein 120A|TBP-interacting protein of 120 kDa A|cullin-associated NEDD8-dissociated protein 1|cullin-associated and neddylation-dissociated protein 1|p120 CAND1
Swissprots	Q96JZ9 Q9H0G2 Q9BTC4 Q9P0H7 Q86VP6 Q8NDJ4 O94918 Q9UF85 Q6PIY4 B2RAU3 Q96T19
Accessions	EAW97171 EAW97172 Q86VP6 AB020636 BAA74852 AF157326 AAF67492 AK000976 BAG50842 AK001791 BAG50975 AK027404 BAB55090 AK027783 BAB55365 AK074922 AK096010 AK129780 AK292456 BAF85145 AK314358 BAG36990 AL133560 CAB63714 AL136810 CAB66744 AL833880 CAD38737 BC004232 AAH04232 BC026220 AAH26220 BC050341 AAH50341 BQ024785 DB064887 DB098973 EU832277 ACE87534 EU832362 ACE86847 NM_018448 NP_060918
Function	Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:21249194}. Nucleus {ECO:0000269|PubMed:21249194}. Note=Predominantly cytoplasmic.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® CAND1 siRNA I - 9824 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

TIP120A CRISPR/Cas9 KO Plasmid (h) - sc-402506 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TIP120A HDR Plasmid (h) - sc-402506-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TIP120A Double Nickase Plasmid (h) - sc-402506-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TIP120A Double Nickase Plasmid (h2) - sc-402506-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TIP120A CRISPR Activation Plasmid (h) - sc-402506-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TIP120A CRISPR Activation Plasmid (h2) - sc-402506-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TIP120A Lentiviral Activation Particles (h) - sc-402506-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TIP120A Lentiviral Activation Particles (h2) - sc-402506-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TIP120A siRNA (h) - sc-37174 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TIP120A shRNA Plasmid (h) - sc-37174-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TIP120A shRNA (h) Lentiviral Particles - sc-37174-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TIP120A RNAi - H00055832-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU010671 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5331 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5331 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09019 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr09019

CAND1 siRNA (Human) - CRJ0957 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CAND1 - MBS8203767 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CAND1 (NM_018448.3) - SHH254185 from Creative biogene Category siRNA Species Reactivities Human

Human CAND1 siRNA - orb271458 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CAND1 shRNA Plasmid (Human) - CHJ0957 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CAND1 miRNA 3'UTR clone - MiUTR4H-TG01598 from Creative biogene Species Reactivities Human

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