CAND1

Gene Symbol CAND1
Entrez Gene 55832
Alt Symbol TIP120, TIP120A
Species Human
Gene Type protein-coding
Description cullin-associated and neddylation-dissociated 1
Other Description TBP interacting protein|TBP-interacting protein 120A|TBP-interacting protein of 120 kDa A|cullin-associated NEDD8-dissociated protein 1|cullin-associated and neddylation-dissociated protein 1|p120 CAND1
Swissprots Q96JZ9 Q9H0G2 Q9BTC4 Q9P0H7 Q86VP6 Q8NDJ4 O94918 Q9UF85 Q6PIY4 B2RAU3 Q96T19
Accessions EAW97171 EAW97172 Q86VP6 AB020636 BAA74852 AF157326 AAF67492 AK000976 BAG50842 AK001791 BAG50975 AK027404 BAB55090 AK027783 BAB55365 AK074922 AK096010 AK129780 AK292456 BAF85145 AK314358 BAG36990 AL133560 CAB63714 AL136810 CAB66744 AL833880 CAD38737 BC004232 AAH04232 BC026220 AAH26220 BC050341 AAH50341 BQ024785 DB064887 DB098973 EU832277 ACE87534 EU832362 ACE86847 NM_018448 NP_060918
Function Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:21249194}. Nucleus {ECO:0000269|PubMed:21249194}. Note=Predominantly cytoplasmic.

CAND1 Antibody - 7433 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using CAND1 Antibody.

CAND1 (D1F2) Rabbit mAb - 8759 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1F2
Western blot analysis of extracts from 293T cells, either mock transfected (-) or transfected with a Myc-tagged cDNA expression construct encoding full-length human CAND1 (hCAND1-Myc, +), using CAND1 (D1F2) Rabbit mAb.

TIP120A (D-9) - sc-373718 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TIP120A (D-9): sc-373718. Western blot analysis of TIP120A expression in HeLa (A) and Jurkat (B) nuclear extracts.

TIP120A (B-8) - sc-137124 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TIP120A (B-8): sc-137124. Western blot analysis of TIP120A expression in HeLa (A) and Jurkat (B) nuclear extracts.

TIP120A (G-3) - sc-137055 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TIP120A (G-3): sc-137055. Western blot analysis of TIP120A expression in Jurkat (A) and HeLa (B) whole cell lysates.

TIP120A (H-85) - sc-25384 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

TIP120A (A-13) - sc-10672 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TIP120A (A-13): sc-10672. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

TIP120A (48) - sc-136400 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TIP120A (48): sc-136400. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

TIP120A (YQ-07) - sc-101180 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TIP120A (YQ-07): sc-101180. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human placenta tissue showing nuclear and cytoplasmic localization.

Anti-TIP120A antibody - ab34850 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TIP120A antibody - ab57658 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
TIP120A antibody (ab57658) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human placenta.

Anti-TIP120A antibody [EPR14241] - N-terminal - ab183748 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14241
All lanes : Anti-TIP120A antibody [EPR14241] - N-terminal (ab183748) at 1/20000 dilutionLane 1 : 293T whole cell lysateLane 2 : Jurkat whole cell lysateLane 3 : Saos-2 whole cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-TIP120A antibody [EPR14242(B)] - C-terminal - ab181216 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14242(B)
All lanes : Anti-TIP120A antibody [EPR14242(B)] - C-terminal (ab181216) at 1/50000 dilutionLane 1 : 293T cell line lysateLane 2 : HeLa cell line lysateLane 3 : Jurkat cell line lysateLane 4 : Saos 2 cell line lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated antibody at 1/1000 dilution

Anti-TIP120 / CAND1 Antibody (N-Terminus) - LS-C127211 from LifeSpan Bioscience

Prices $680.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TIP120 / CAND1 Antibody (aa600-650) - LS-C289608 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TIP120 / CAND1 Antibody (aa112-161) - LS-C31482 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Fetal Brain Lysate

Anti-TIP120 / CAND1 Antibody (aa1180-1230) - LS-C289610 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse CAND1 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma (left) and mouse hybridoma tumor (right). Antibody: Affinity purified rabbit anti-CAND1 used at a dilution of 1:5000 (0.2and 1:1000 (1 Detection: DAB.

Anti-TIP120 / CAND1 Antibody (N-Terminus) IHC-plus™ - LS-B347 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-CAND1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B347 dilution 1:500.

Anti-TIP120 / CAND1 Antibody (clone 5D7) - LS-C133780 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5D7
Immunoperoxidase of monoclonal antibody to CAND1 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]

Anti-TIP120 / CAND1 Antibody (C-Terminus) IHC-plus™ - LS-B5610 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CAND1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5610 concentration 5 ug/ml.

TIP120A Antibody (5D7) - H00055832-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5D7
Western Blot: TIP120A Antibody (5D7) [H00055832-M01] - CAND1 monoclonal antibody (M01), clone 5D7 Analysis of CAND1 expression in Hela S3 NE.

TIP120A Antibody (4D10) - H00055832-M04 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4D10
Western Blot: TIP120A Antibody (4D10) [H00055832-M04] - Analysis of CAND1 expression in Raw 264.7 (Cat # L024V1).

TIP120A Antibody - NBP1-49918 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TIP120A Antibody [NBP1-49918] - Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 ug) and mouse NIH3T3 (M; 50 ug) cells. Antibodies: Affinity purified rabbit anti-TIP120A antibody NBP1-49918 used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate. TIP120A was also immunoprecipitated by rabbit anti-TIP120A antibody NBP1-49917, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 30 seconds (B).

TIP120A Antibody - NBP2-38974 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TIP120A Antibody [NBP2-38974] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG. Lane 4: Human Plasma. Lane 5: Human liver tissue. Lane 6: Human tonsil tissue

TIP120A Antibody (1G5) - H00055832-M05 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G5
Western Blot: TIP120A Antibody (1G5) [H00055832-M05] - Analysis of CAND1 expression in Raw 264.7 (Cat # L024V1).
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