TTC3

Gene Symbol	TTC3
Entrez Gene	7267
Alt Symbol	DCRR1, RNF105, TPRDIII
Species	Human
Gene Type	protein-coding
Description	tetratricopeptide repeat domain 3
Other Description	E3 ubiquitin-protein ligase TTC3\|RING finger protein 105\|TPR repeat protein 3\|TPR repeat protein D\|tetratricopeptide repeat protein 3
Swissprots	Q6P578 O60767 Q569I2 D3DSH3 A8K7H7 Q9UEK4 D3DSH2 B2RPA7 P78477 P53804 D3DSG9 P78476
Accessions	EAX09716 EAX09717 EAX09718 EAX09719 EAX09720 EAX09721 EAX09722 EAX09723 P53804 AJ001866 CAA05057 AK125473 AK126194 AK126418 AK291992 BAF84681 AK297921 BAG60239 AK299991 BAG61811 AY523634 AAT28185 BC026260 BC047867 BC063033 AAH63033 BC092466 AAH92466 BC137345 AAI37346 BI915053 BQ893819 CA420000 CR936616 CAI56759 D83077 BAA11769 D83327 BAA23666 D84294 BAA12301 D84295 BAA12302 D84296 BAA12303 XM_005261048 XP_005261105 XM_005261049 XP_005261106 XM_005261050 XP_005261107 XM_005261052 XP_005261109 XM_005261053 XP_005261110 XM_005261054 XP_005261111 XM_005261055 XP_005261112 XM_005261056 XP_005261113 XM_011529738 XP_011528040 XM_011529739 XP_011528041 XM_011529740 XP_011528042 XM_011529741 XP_011528043 XM_011529742 XP_011528044 NM_001001894 NP_001001894 NM_003316 NP_003307
Function	E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'- polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT. {ECO:0000269\|PubMed:17488780, ECO:0000269\|PubMed:20059950}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:20059950}.
Tissue Specificity	Found in all tissues examined.

TTC3 (E-20) - sc-49562 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

TTC3 (F-19) - sc-49563 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-TTC3 antibody - ab121783 from Abcam

Prices	$443.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

ab121783, staining TTC3 in paraffin-embedded Human Liver tissue, by Immunohistochemistry.

Anti-TTC3 antibody - ab121514 from Abcam

Prices	$443.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

ab121514, at a 1/100 dilution, staining TTC3 in paraffin emebedded Human kidney tissue by Immunohistochemistry.

Anti-TTC3 antibody - ab80061 from Abcam

Prices	$370.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TTC3 Antibody (N-Terminus) - LS-C144972 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TTC3 Antibody (clone 2D10) - LS-C198379 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2D10

Detection limit for recombinant GST tagged TTC3 is approximately 1 ng/ml as a capture antibody.

TTC3 Antibody - NBP1-84293 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: TTC3 Antibody [NBP1-84293] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10. Lane 2: HEL

TTC3 Antibody - NBP1-84292 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry-Paraffin: TTC3 Antibody [NBP1-84292] - Staining of human kidney shows cytoplasmic positivity in cells in tubules.

TTC3 Antibody - H00007267-A01 from Novus Biologicals

Prices	$269.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

TTC3 Antibody (2D10) - H00007267-M09 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2D10

ELISA: TTC3 Antibody (2D10) [H00007267-M09] - Detection limit for recombinant GST tagged TTC3 is approximately 1ng/ml as a capture antibody.

RNF105 Polyclonal Antibody - bs-9147R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TTC3 antibody produced in rabbit - HPA023964 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-TTC3: <B>Cat. No. HPA023964</B>: Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.

Anti-TTC3 antibody produced in rabbit - HPA016810 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-TTC3: <B>Cat. No. HPA016810</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic and nuclear positivity in tubular cells.

TTC3-Antibody-monoclonal-M09 - AT4387a from Abgent, a WuXi AppTec company

Prices	$315.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2D10

TTC3 / RNF105 antibody - AP55323SU-N from Acris Antibodies

Prices	$460.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

TTC3 / RNF105 antibody - H00007267-A01 from Acris Antibodies

Prices	$300.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

TTC3 / RNF105 antibody - H00007267-M09 from Acris Antibodies

Prices	$360.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2D10

Anti-TTC3 (aa 1-110) polyclonal antibody - DPAB-DC3134 from Creative Diagnostics

Host	Mouse
Clonality	Polyclonal

Anti-TTC3 (aa 917-1049) polyclonal antibody - DPABH-18389 from Creative Diagnostics

Host	Rabbit
Clonality	Polyclonal

Anti-TTC3 (aa 19-145) polyclonal antibody - DPABH-20102 from Creative Diagnostics

Host	Rabbit
Clonality	Polyclonal

Anti-tetratricopeptide repeat domain 3 - 08A007267 from MP Biomedicals

Prices	$456.30
Sizes	100 μg
Host	Mouse
Clonality	Monoclonal
Clone	2D10

Tetratricopeptide repeat protein 3 (TTC3/TPRD)... - pab0532 from Covalab

Host	Rabbit
Clonality	Polyclonal

RNF105 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-9147R-A350 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

RNF105 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-9147R-A488 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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