TTC3

Gene Symbol	TTC3
Entrez Gene	7267
Alt Symbol	DCRR1, RNF105, TPRDIII
Species	Human
Gene Type	protein-coding
Description	tetratricopeptide repeat domain 3
Other Description	E3 ubiquitin-protein ligase TTC3|RING finger protein 105|TPR repeat protein 3|TPR repeat protein D|tetratricopeptide repeat protein 3
Swissprots	Q6P578 O60767 Q569I2 D3DSH3 A8K7H7 Q9UEK4 D3DSH2 B2RPA7 P78477 P53804 D3DSG9 P78476
Accessions	EAX09716 EAX09717 EAX09718 EAX09719 EAX09720 EAX09721 EAX09722 EAX09723 P53804 AJ001866 CAA05057 AK125473 AK126194 AK126418 AK291992 BAF84681 AK297921 BAG60239 AK299991 BAG61811 AY523634 AAT28185 BC026260 BC047867 BC063033 AAH63033 BC092466 AAH92466 BC137345 AAI37346 BI915053 BQ893819 CA420000 CR936616 CAI56759 D83077 BAA11769 D83327 BAA23666 D84294 BAA12301 D84295 BAA12302 D84296 BAA12303 XM_005261048 XP_005261105 XM_005261049 XP_005261106 XM_005261050 XP_005261107 XM_005261052 XP_005261109 XM_005261053 XP_005261110 XM_005261054 XP_005261111 XM_005261055 XP_005261112 XM_005261056 XP_005261113 XM_011529738 XP_011528040 XM_011529739 XP_011528041 XM_011529740 XP_011528042 XM_011529741 XP_011528043 XM_011529742 XP_011528044 NM_001001894 NP_001001894 NM_003316 NP_003307
Function	E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'- polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT. {ECO:0000269|PubMed:17488780, ECO:0000269|PubMed:20059950}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:20059950}.
Tissue Specificity	Found in all tissues examined.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Recombinant Human TTC3 Protein - H00007267-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TTC3 / RNF105 - H00007267-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TTC3 / RNF105 - H00007267-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TTC3 fusion protein - Ag16576 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

TTC3 fusion protein - ag16502 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human TTC3, His-tagged - TTC3-31249TH from Creative Biomart Category Protein Source E. coli

Recombinant Human TTC3, His-tagged - TTC3-3473H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human E3 ubiquitin-protein ligase TTC3(TTC3) ,partial - CSB-YP025223HU CSB-EP025223HU CSB-BP025223HU CSB-MP025223HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TTC3 Recombinant Protein Antigen - NBP1-84293PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TTC3 Recombinant Protein Antigen - NBP1-84292PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TTC3 Peptide, Human - M34GP16796H from Creative Peptides Category Peptide Source Synthetic. Species Human

TTC3 Recombinant Protein Antigen - NBP2-55316PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

E3 ubiquitin-protein ligase TTC3 (TTC3), partial, Recombinant Protein - MBS966873 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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