EYA2

Gene Symbol	EYA2
Entrez Gene	2139
Alt Symbol	EAB1
Species	Human
Gene Type	protein-coding
Description	EYA transcriptional coactivator and phosphatase 2
Other Description	eyes absent homolog 2
Swissprots	Q9H4S3 Q86U84 Q9UIX7 Q96CV6 Q5JSW8 Q9NPZ4 Q9H4S9 Q99503 Q9BWF6 O00167 Q96H97 Q99812
Accessions	CAA71310 CAI23166 EAW75720 EAW75721 EAW75722 O00167 AF055015 AAC09362 AF387364 AAK62466 AF455147 AAL57874 AF455148 AAL57875 AF455149 AAL57877 AF455150 AAL57878 AJ007992 CAA07815 AK093582 AK293032 BAF85721 AY705349 AAU11525 BC000289 AAH00289 BC008803 AAH08803 BC013882 AAH13882 BT006682 AAP35328 JF432289 ADZ15506 U71207 AAB51120 U81601 AAB42065 XM_005260327 XP_005260384 XM_011528687 XP_011526989 NM_005244 NP_005235 NM_172110 NP_742108 NM_172111 NM_172112 NM_172113
Function	Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1. {ECO:0000269|PubMed:19351884, ECO:0000269|PubMed:21706047}.
Subcellular Location	Cytoplasm. Nucleus. Note=Retained in the cytoplasm via interaction with GNAZ and GNAI2. Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus.
Tissue Specificity	Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EYA2 (N-16) - sc-15097 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

EYA2 (C-15) - sc-15100 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

EYA2 (F-18) - sc-100325 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-EYA2 antibody - ab54713 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-EYA2 antibody - ab95874 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-EYA2 antibody [8C9D9] - N-terminal - ab170135 from Abcam Host Mouse Clonality Monoclonal Clone 8C9D9

Anti-EYA2 antibody [EPR2942] - ab92505 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR2942

Anti-EYA2 Antibody (N-Terminus, clone EPR2942) - LS-C105667 from LifeSpan Bioscience Prices $450.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR2942

Anti-EYA2 Antibody (aa164-272) - LS-C128904 from LifeSpan Bioscience Prices $445.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-EYA2 Antibody (aa164-272, clone 10C181, Azide-free) - LS-C183611 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone 10C181

Anti-EYA2 Antibody (aa200-249) - LS-C145429 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-EYA2 Antibody (aa216-244, AP) - LS-C256894 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EYA2 Antibody (aa216-244, APC) - LS-C256895 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EYA2 Antibody (aa216-244, Azide-free, HRP) - LS-C256898 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EYA2 Antibody (aa216-244, Biotin) - LS-C256897 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EYA2 Antibody (aa216-244, FITC) - LS-C256896 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EYA2 Antibody (aa216-244, PE) - LS-C256900 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EYA2 Antibody - LS-C310300 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-EYA2 Antibody - LS-C318373 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-EYA2 Antibody (clone 2F8) - LS-C197173 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2F8

Anti-EYA2 Antibody (aa216-244) - LS-C167871 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-EYA2 Antibody (HRP) - LS-C318375 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-EYA2 Antibody (aa100-150) - LS-C286941 from LifeSpan Bioscience Prices $415.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EYA2 Antibody (FITC) - LS-C318376 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-EYA2 Antibody (aa1-50) - LS-C289406 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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