EYA2

Gene Symbol EYA2
Entrez Gene 2139
Alt Symbol EAB1
Species Human
Gene Type protein-coding
Description EYA transcriptional coactivator and phosphatase 2
Other Description eyes absent homolog 2
Swissprots Q9H4S3 Q86U84 Q9UIX7 Q96CV6 Q5JSW8 Q9NPZ4 Q9H4S9 Q99503 Q9BWF6 O00167 Q96H97 Q99812
Accessions CAA71310 CAI23166 EAW75720 EAW75721 EAW75722 O00167 AF055015 AAC09362 AF387364 AAK62466 AF455147 AAL57874 AF455148 AAL57875 AF455149 AAL57877 AF455150 AAL57878 AJ007992 CAA07815 AK093582 AK293032 BAF85721 AY705349 AAU11525 BC000289 AAH00289 BC008803 AAH08803 BC013882 AAH13882 BT006682 AAP35328 JF432289 ADZ15506 U71207 AAB51120 U81601 AAB42065 XM_005260327 XP_005260384 XM_011528687 XP_011526989 NM_005244 NP_005235 NM_172110 NP_742108 NM_172111 NM_172112 NM_172113
Function Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1. {ECO:0000269|PubMed:19351884, ECO:0000269|PubMed:21706047}.
Subcellular Location Cytoplasm. Nucleus. Note=Retained in the cytoplasm via interaction with GNAZ and GNAI2. Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus.
Tissue Specificity Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.

EYA2 (N-16) - sc-15097 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EYA2 (N-16): sc-15097. Western blot analysis of EYA2 expression in non-transfected: sc-117752 (A) and mouse EYA2 transfected: sc-126819 (B) 293T whole cell lysates.

EYA2 (C-15) - sc-15100 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

EYA2 (F-18) - sc-100325 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
EYA2 (F-18): sc-100325. Western blot analysis of EYA2 expression in IMR-32 whole cell lysate.

Anti-EYA2 antibody - ab54713 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-EYA2 antibody - ab95874 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling EYA2 with ab95874 at 1/1000 (1µg/ml). Detection: DAB.

Anti-EYA2 antibody [8C9D9] - N-terminal - ab170135 from Abcam

Host Mouse
Clonality Monoclonal
Clone 8C9D9
Immunohistochemical analysis of formaldehyde-fixed, paraffin-embedded Human adenocarcinoma tissue labeling EYA2 with ab170135 at 1/50 dilution. HRP-conjugated Goat anti-mouse IgG (dilution 1/50) was used as secondary antibody.

Anti-EYA2 antibody [EPR2942] - ab92505 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2942
All lanes : Anti-EYA2 antibody [EPR2942] (ab92505) at 1/50000 dilutionLane 1 : Y-79 cell lysateLane 2 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP-labeled goat anti-rabbit at 1/2000 dilution

Anti-EYA2 Antibody (N-Terminus, clone EPR2942) - LS-C105667 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2942

Anti-EYA2 Antibody (aa164-272) - LS-C128904 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-EYA2 Antibody (aa164-272, clone 10C181, Azide-free) - LS-C183611 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10C181

Anti-EYA2 Antibody (aa200-249) - LS-C145429 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
EYA2 antibody LS-C145429 Western blot of Rat Muscle lysate. Antibody concentration 1 ug/ml.

Anti-EYA2 Antibody (aa216-244, AP) - LS-C256894 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EYA2 Antibody (aa216-244, APC) - LS-C256895 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EYA2 Antibody (aa216-244, Azide-free, HRP) - LS-C256898 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EYA2 Antibody (aa216-244, Biotin) - LS-C256897 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EYA2 Antibody (aa216-244, FITC) - LS-C256896 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EYA2 Antibody (aa216-244, PE) - LS-C256900 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EYA2 Antibody - LS-C310300 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EYA2 Antibody - LS-C318373 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EYA2 Antibody (clone 2F8) - LS-C197173 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F8
Immunofluorescence of monoclonal antibody to EYA2 on HeLa cell. [antibody concentration 10 ug/ml]

Anti-EYA2 Antibody (aa216-244) - LS-C167871 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of EYA2 (arrow) using rabbit polyclonal EYA2 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the EYA2 gene.

Anti-EYA2 Antibody (HRP) - LS-C318375 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EYA2 Antibody (aa100-150) - LS-C286941 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human EYA2 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-EYA2 used at a dilution of 1:250.

Anti-EYA2 Antibody (FITC) - LS-C318376 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EYA2 Antibody (aa1-50) - LS-C289406 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human EYA2 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-EYA2 used at a dilution of 1:1000 (1 Detection: DAB.
Search more