EYA2

Gene Symbol	EYA2
Entrez Gene	2139
Alt Symbol	EAB1
Species	Human
Gene Type	protein-coding
Description	EYA transcriptional coactivator and phosphatase 2
Other Description	eyes absent homolog 2
Swissprots	Q9H4S3 Q86U84 Q9UIX7 Q96CV6 Q5JSW8 Q9NPZ4 Q9H4S9 Q99503 Q9BWF6 O00167 Q96H97 Q99812
Accessions	CAA71310 CAI23166 EAW75720 EAW75721 EAW75722 O00167 AF055015 AAC09362 AF387364 AAK62466 AF455147 AAL57874 AF455148 AAL57875 AF455149 AAL57877 AF455150 AAL57878 AJ007992 CAA07815 AK093582 AK293032 BAF85721 AY705349 AAU11525 BC000289 AAH00289 BC008803 AAH08803 BC013882 AAH13882 BT006682 AAP35328 JF432289 ADZ15506 U71207 AAB51120 U81601 AAB42065 XM_005260327 XP_005260384 XM_011528687 XP_011526989 NM_005244 NP_005235 NM_172110 NP_742108 NM_172111 NM_172112 NM_172113
Function	Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1. {ECO:0000269|PubMed:19351884, ECO:0000269|PubMed:21706047}.
Subcellular Location	Cytoplasm. Nucleus. Note=Retained in the cytoplasm via interaction with GNAZ and GNAI2. Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus.
Tissue Specificity	Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EYA2 protein fragment - ab124581 from Abcam Category Protein Source E. coli Species Human

EYA2 Antibody Blocking Peptide - LS-E4724 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EYA2 Antibody Blocking Peptide - LS-E11362 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EYA2 Recombinant Protein - H00002139-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human EYA2 Protein - NBP1-99047 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E. coli Species Human

EYA2-Antibody-Center-Blocking-Peptide - BP17094c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human EYA2 protein - orb168320 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

Human EYA2 protein - orb244192 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Eya2 Blocking Peptide - 33R-2272 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EYA2 protein (His tag) - 80R-2220 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

EYA2 / EAB1 (244-514, His-tag) - AR50303PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

EYA2 / EAB1 (244-514, His-tag) - AR50303PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

EYA2 / EAB1 - H00002139-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

EYA2, 244-514aa, Human, His tag, E.coli - 01-P1478 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

EYA2 fusion protein - ag1860 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

EYA2 Human - PRPS-1078 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source E.coli. Species Human

Recombinant Human Eyes Absent Homolog 2 Protein - BP002878-PRO-1071 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

EYA2, 244-514aa, Recombinant Protein - GWB-P0560A from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

Recombinant human Eyes absent homolog 2 - CSB-EP007907HU CSB-BP007907HU CSB-MP007907HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant human Eyes absent homolog 2 - CSB-EP007907HU from Cusabio Category Protein Source E.coli Species Human

Recombinant Human Eyes absent homolog 2(EYA2) - CSB-YP007907HU CSB-BP007907HU CSB-MP007907HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

EYA2, 244-514aa, Human, His tag, E.coli - ATGP1478 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

Recombinant Human EYA2 protein, His-tagged - EYA2-18H from Creative Biomart Category Protein Source E. coli Species Human

EYA2 Recombinant Protein Antigen - NBP1-84026PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Eyes Absent Homolog 2 Protein (Recombinant) - abx262508 from Abbexa Category Protein

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