EYA2

Gene Symbol	EYA2
Entrez Gene	2139
Alt Symbol	EAB1
Species	Human
Gene Type	protein-coding
Description	EYA transcriptional coactivator and phosphatase 2
Other Description	eyes absent homolog 2
Swissprots	Q9H4S3 Q86U84 Q9UIX7 Q96CV6 Q5JSW8 Q9NPZ4 Q9H4S9 Q99503 Q9BWF6 O00167 Q96H97 Q99812
Accessions	CAA71310 CAI23166 EAW75720 EAW75721 EAW75722 O00167 AF055015 AAC09362 AF387364 AAK62466 AF455147 AAL57874 AF455148 AAL57875 AF455149 AAL57877 AF455150 AAL57878 AJ007992 CAA07815 AK093582 AK293032 BAF85721 AY705349 AAU11525 BC000289 AAH00289 BC008803 AAH08803 BC013882 AAH13882 BT006682 AAP35328 JF432289 ADZ15506 U71207 AAB51120 U81601 AAB42065 XM_005260327 XP_005260384 XM_011528687 XP_011526989 NM_005244 NP_005235 NM_172110 NP_742108 NM_172111 NM_172112 NM_172113
Function	Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1. {ECO:0000269|PubMed:19351884, ECO:0000269|PubMed:21706047}.
Subcellular Location	Cytoplasm. Nucleus. Note=Retained in the cytoplasm via interaction with GNAZ and GNAI2. Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus.
Tissue Specificity	Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Eyes absent homolog 2 (EYA2), Human, ELISA Kit - CSB-EL007907HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 2.34 pg/ml Range 9.37 pg/ml-600 pg/ml

eyes absent homolog 2 (Drosophila) , ELISA Kit - MBS917939 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human EYA2 is typically less than 2.34 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 9. 37 pg/ml -600 pg/ml.

Human Eyes absent homolog 2(EYA2) ELISA kit - CSB-EL007907HU from Cusabio Category ELISA Kit Sensitivity 2.34 pg/ml Range 9.37 pg/ml-600 pg/ml

Human Eyes absent homolog 2 (EYA2) ELISA Kit - EKC33651 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 2.34 pg/ml Range 9.37 pg/ml-600 pg/ml

Human EYA2 ELISA Kit - E013930 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human EYA2 is typically less than 2.34 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean

EYA2 ELISA Kit (Human) (OKCA00675) - OKCA00675 from Aviva Systems Biology Category ELISA Kit Prices $590.00 Sizes 96 wells Sensitivity 2.34 pg/mL Range 9.37 pg/mL-600 pg/mL

Human EYA2 ELISA Kit - orb404408 from Biorbyt Category ELISA Kit Sensitivity 2.34 pg/ml Range 9.37 pg/ml-600 pg/ml

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