Gene Symbol | NPNT |
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Entrez Gene | 255743 |
Alt Symbol | EGFL6L, POEM |
Species | Human |
Gene Type | protein-coding |
Description | nephronectin |
Other Description | preosteoblast EGF-like repeat protein with MAM domain |
Swissprots | D6RCA1 B4E2H7 A8K1W4 E9PE64 E9PCK8 B4DIT4 E9PF04 B4E3H2 A6NFT9 E9PCQ1 Q6UXI9 B4DYK3 |
Accessions | EAX06194 EAX06195 EAX06196 EAX06197 Q6UXI9 AK172856 AK290029 BAF82718 AK295772 BAG58596 AK302477 BAG63765 AK304279 BAG65139 AK304721 BAG65484 AL832465 AW607534 AY358336 AAQ88702 BC131587 BC166654 AAI66654 BM970581 CD109759 XM_005262888 XP_005262945 XM_005262890 XP_005262947 XM_011531820 XP_011530122 XM_011531821 XP_011530123 XM_011531822 XP_011530124 XM_011531823 XP_011530125 XM_011531824 XP_011530126 XM_011531825 XP_011530127 XM_011531826 XP_011530128 NM_198278 NM_001033047 NP_001028219 NM_001184690 NP_001171619 NM_001184691 NP_001171620 NM_001184692 NP_001171621 NM_001184693 NP_001171622 |
Function | Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Trapped on the cell surface or in the extracellular matrix. {ECO:0000250}. |
Tissue Specificity | Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels. {ECO:0000269|PubMed:15754038}. |
POEM CRISPR/Cas9 KO Plasmid (h) - sc-407245 from Santa Cruz Biotechnology
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POEM HDR Plasmid (h) - sc-407245-HDR from Santa Cruz Biotechnology
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POEM Double Nickase Plasmid (h) - sc-407245-NIC from Santa Cruz Biotechnology
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POEM Double Nickase Plasmid (h2) - sc-407245-NIC-2 from Santa Cruz Biotechnology
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POEM CRISPR Activation Plasmid (h) - sc-407245-ACT from Santa Cruz Biotechnology
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POEM CRISPR Activation Plasmid (h2) - sc-407245-ACT-2 from Santa Cruz Biotechnology
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POEM Lentiviral Activation Particles (h) - sc-407245-LAC from Santa Cruz Biotechnology
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POEM Lentiviral Activation Particles (h2) - sc-407245-LAC-2 from Santa Cruz Biotechnology
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POEM siRNA (h) - sc-88967 from Santa Cruz Biotechnology
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POEM shRNA Plasmid (h) - sc-88967-SH from Santa Cruz Biotechnology
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POEM shRNA (h) Lentiviral Particles - sc-88967-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN15463 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15463 from Sigma-Aldrich
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NPNT siRNA (Human) - CRJ6729 from Cohesion Biosciences
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shRNA set against Human Npnt (NM_001033047.2) - SHH354348 from Creative biogene
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Human NPNT siRNA - orb277230 from Biorbyt
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NPNT shRNA Plasmid (Human) - CHJ6729 from Cohesion Biosciences
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