| Gene Symbol |
SHOC2
|
| Entrez Gene |
8036
|
| Alt Symbol |
SIAA0862, SOC2, SUR8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
soc-2 suppressor of clear homolog (C. elegans)
|
| Other Description |
leucine-rich repeat protein SHOC-2
|
| Swissprots |
Q5VZS8 Q5VZS9 B3KR23 A8K9W8 Q9UQ13 O76063
|
| Accessions |
EAW49548 EAW49549 EAW49550 Q9UQ13 AB020669 BAA74885 AF054828 AAC25698 AF068920 AAC39856 AI202318 AK090820 BAG52235 AK292833 BAF85522 AK293271 BAG56800 BC044752 BC050445 AAH50445 BX649055 DB451165 XM_011540216 XP_011538518 NM_001269039 NP_001255968 NM_007373 NP_031399
|
| Function |
Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. {ECO:0000269|PubMed:10783161, ECO:0000269|PubMed:16630891}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19684605}. Nucleus {ECO:0000269|PubMed:19684605}. Note=Translocates from cytoplasm to nucleus upon growth factor stimulation.
|