SLC4A5

Gene Symbol	SLC4A5
Entrez Gene	57835
Alt Symbol	NBC4
Species	Human
Gene Type	protein-coding
Description	solute carrier family 4 (sodium bicarbonate cotransporter), member 5
Other Description	NBCe2|electrogenic sodium bicarbonate cotransporter 4
Swissprots	Q9BY07 Q59EQ9 Q96DS8 Q8WXD3 Q9HBU5 Q96DS7 Q8WXD7 Q32MA7
Accessions	AAF03523 AAX93062 AAY14938 EAW99688 EAW99689 EAW99690 EAW99691 EAW99692 EAW99693 Q9BY07 AB209752 BAD92989 AF243499 AAK26741 AF293337 AAK97072 AF293338 AAK97073 AF452248 AAL48291 AF453528 AAL50802 BC109221 AAI09222 DB455137 NM_021196 NP_067019 NM_133478 NP_597812 NM_033323 NM_133479
Function	Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH. {ECO:0000250|UniProtKB:Q6RI88, ECO:0000269|PubMed:11788353, ECO:0000269|PubMed:11997242, ECO:0000269|PubMed:12388414}.
Subcellular Location	Apical cell membrane {ECO:0000269|PubMed:17715183}; Multi-pass membrane protein {ECO:0000269|PubMed:17715183}. Note=Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla. {ECO:0000269|PubMed:17715183}.
Tissue Specificity	Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle. {ECO:0000269|PubMed:10978526, ECO:0000269|PubMed:11087115, ECO:0000269|PubMed:11788353, ECO:0000269|PubMed:17715183}.
Top Pathways	Bile secretion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SLC4A5 / NBC4 ELISA Kit (Sandwich ELISA) - LS-F7821 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.119 ng/ml Range 0.313-20 ng/ml

Human NBC4 ELISA Kit - abx152459 from Abbexa Category ELISA Kit Sensitivity 0.119 ng/ml Range 0.313 ng/ml - 20 ng/ml

Electrogenic Sodium Bicarbonate Cotransporter 4 (NBC4), Human, ELISA Kit - SEE365Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.119ng/mL Range 0.312-20ng/mL

Electrogenic Sodium Bicarbonate Cotransporter 4, ELISA Kit - MBS087040 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic Sodium Bicarbonate Cotransporter 4, ELISA Kit - MBS075786 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic Sodium Bicarbonate Cotransporter 4, ELISA Kit - MBS063265 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic Sodium Bicarbonate Cotransporter 4, ELISA Kit - MBS108150 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic Sodium Bicarbonate Cotransporter 4, ELISA Kit - MBS084878 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic Sodium Bicarbonate Cotransporter 4, ELISA Kit - MBS085912 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic Sodium Bicarbonate Cotransporter 4, ELISA Kit - MBS073399 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Electrogenic Sodium Bicarbonate Cotransporter 4 (NBC4), ELISA Kit - MBS2023174 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human NBC4 is typically less than 0.119ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.312-20ng/mL

solute carrier family 4, sodium bicarbonate cotransporter, member 5, ELISA Kit - MBS9331753 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Electrogenic Sodium Bicarbonate Cotransporter 4 (NBC4) - SEE365Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.119ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Electrogenic Sodium Bicarbonate Cotransporter 4 (NBC4) - SEE365Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.119ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human Electrogenic Sodium Bicarbonate Cotransporter 4 (NBC4) ELISA Kit - EKU03859 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.119 ng/mL Range 0.312-20 ng/mL

Electrogenic Sodium Bicarbonate Cotransporter 4 (NBC4), Human, ELISA Kit - DL-NBC4-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human NBC4 ELISA Kit - abx572657 from Abbexa Category ELISA Kit Sensitivity 0.119 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human NBC4 ELISA Kit - E012901 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human NBC4 is typically less than 0.119ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by addi

Human SLC4A5 ELISA Kit - E036069 from Biobool Category ELISA Kit

Human Electrogenic sodium bicarbonate cotransporter 4 (SLC4A5) ELISA Kit - AE18464HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.119 ng/mL Range 0.312-20 ng/mL

Electrogenic Sodium Bicarbonate Cotransporter 4 (NBC4), ELISA Kit - MBS451491 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.119ng/mL Range 0.312-20ng/mL

Electrogenic Sodium Bicarbonate Cotransporter 4 (NBC4), ELISA Kit - MBS9379673 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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