SLC4A5

Gene Symbol SLC4A5
Entrez Gene 57835
Alt Symbol NBC4
Species Human
Gene Type protein-coding
Description solute carrier family 4 (sodium bicarbonate cotransporter), member 5
Other Description NBCe2|electrogenic sodium bicarbonate cotransporter 4
Swissprots Q9BY07 Q59EQ9 Q96DS8 Q8WXD3 Q9HBU5 Q96DS7 Q8WXD7 Q32MA7
Accessions AAF03523 AAX93062 AAY14938 EAW99688 EAW99689 EAW99690 EAW99691 EAW99692 EAW99693 Q9BY07 AB209752 BAD92989 AF243499 AAK26741 AF293337 AAK97072 AF293338 AAK97073 AF452248 AAL48291 AF453528 AAL50802 BC109221 AAI09222 DB455137 NM_021196 NP_067019 NM_133478 NP_597812 NM_033323 NM_133479
Function Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH. {ECO:0000250|UniProtKB:Q6RI88, ECO:0000269|PubMed:11788353, ECO:0000269|PubMed:11997242, ECO:0000269|PubMed:12388414}.
Subcellular Location Apical cell membrane {ECO:0000269|PubMed:17715183}; Multi-pass membrane protein {ECO:0000269|PubMed:17715183}. Note=Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla. {ECO:0000269|PubMed:17715183}.
Tissue Specificity Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle. {ECO:0000269|PubMed:10978526, ECO:0000269|PubMed:11087115, ECO:0000269|PubMed:11788353, ECO:0000269|PubMed:17715183}.
Top Pathways Bile secretion

NBC4 (E-14) - sc-168713 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NBC4 (E-14): sc-168713. Western blot analysis of NBC4 expression in SUP-T1 (A), Raji (B) and Daudi (C) whole cell lysates.

NBC4 (K-14) - sc-168715 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SLC4A5 antibody - ab99131 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SLC4A5 antibody (ab99131) at 1 µg/ml + THP-1 cell lysate at 10 µg

Anti-SLC4A5 / NBC4 Antibody (aa148-197) - LS-C135151 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SLC4A5 antibody LS-C135151 Western blot of HepG2 cell lysate.

Anti-SLC4A5 / NBC4 Antibody (aa899-948) - LS-C110847 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SLC4A5 antibody LS-C110847 Western blot of THP-1 cell lysate.

SLC4A5 Antibody - NBP1-59528 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SLC4A5 Antibody [NBP1-59528] - THP-1 cell lysate, concentration 0.2-1 ug/ml.

SLC4A5 Antibody - NBP1-82595 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Immunohistochemistry: SLC4A5 Antibody [NBP1-82595] - Staining of human kidney shows strong cytoplasmic positivity in tubules.

Anti-SLC4A5 antibody produced in rabbit - SAB2105549 from Sigma-Aldrich

Prices $347.50, $347.50
Sizes 50 µg, 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SLC4A5: <B>Cat. No. SAB2105549</B>: SLC4A5 in THP-1 cell lysates with SLC4A5 antibody at 1.0 μg/mL.

Anti-SLC4A5 antibody produced in rabbit - HPA036621 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SLC4A5: <B>Cat. No. HPA036621</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in tubules.

SLC4A5 antibody - N-terminal region (ARP44020_P050) - ARP44020_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SLC4A5 antibody - middle region (ARP44021_P050) - ARP44021_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SLC4A5 antibody - 70R-6438 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

SLC4A5 antibody - 70R-8589 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

SLC4A5 Antibody - GWB-MP690F from Genway Biotech

Prices $368.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

SLC4A5 Antibody - GWB-MP689E from Genway Biotech

Prices $368.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Monoclonal Antibody to Electrogenic Sodium Bicarbonate Cotransporter 4 (NBC4) - MAE365Hu21 from Uscn Life Science Inc.

Host Mouse
Clonality Monoclonal

Polyclonal Antibody to Electrogenic Sodium Bicarbonate Cotransporter 4 (NBC4) - PAE365Hu01 from Uscn Life Science Inc.

Host Rabbit
Clonality Polyclonal

SLC4A5, Polyclonal Antibody - MBS5301822 from MyBioSource

Prices $455.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

SLC4A5, Polyclonal Antibody - MBS5300921 from MyBioSource

Prices $455.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

SLC4A5 / NBC4 antibody - TA333725 from Acris Antibodies

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
WB Suggested Anti-SLC4A5 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:12500; Positive Control: HepG2 cell lysate

SLC4A5 / NBC4 antibody - TA333726 from Acris Antibodies

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
WB Suggested Anti-SLC4A5 Antibody Titration: 0.2-1 ug/ml; Positive Control: THP-1 cell lysate

Anti-SLC4A5 polyclonal antibody - CABT-BL143 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-SLC4A5 antibody - STJ112467 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal
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