| Gene Symbol |
SLC4A5
|
| Entrez Gene |
57835
|
| Alt Symbol |
NBC4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 4 (sodium bicarbonate cotransporter), member 5
|
| Other Description |
NBCe2|electrogenic sodium bicarbonate cotransporter 4
|
| Swissprots |
Q9BY07 Q59EQ9 Q96DS8 Q8WXD3 Q9HBU5 Q96DS7 Q8WXD7 Q32MA7
|
| Accessions |
AAF03523 AAX93062 AAY14938 EAW99688 EAW99689 EAW99690 EAW99691 EAW99692 EAW99693 Q9BY07 AB209752 BAD92989 AF243499 AAK26741 AF293337 AAK97072 AF293338 AAK97073 AF452248 AAL48291 AF453528 AAL50802 BC109221 AAI09222 DB455137 NM_021196 NP_067019 NM_133478 NP_597812 NM_033323 NM_133479
|
| Function |
Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH. {ECO:0000250|UniProtKB:Q6RI88, ECO:0000269|PubMed:11788353, ECO:0000269|PubMed:11997242, ECO:0000269|PubMed:12388414}.
|
| Subcellular Location |
Apical cell membrane {ECO:0000269|PubMed:17715183}; Multi-pass membrane protein {ECO:0000269|PubMed:17715183}. Note=Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla. {ECO:0000269|PubMed:17715183}.
|
| Tissue Specificity |
Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle. {ECO:0000269|PubMed:10978526, ECO:0000269|PubMed:11087115, ECO:0000269|PubMed:11788353, ECO:0000269|PubMed:17715183}.
|
| Top Pathways |
Bile secretion
|