TERF1
| Gene Symbol | TERF1 |
|---|---|
| Entrez Gene | 7013 |
| Alt Symbol | PIN2, TRBF1, TRF, TRF1, hTRF1-AS, t-TRF1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | telomeric repeat binding factor (NIMA-interacting) 1 |
| Other Description | NIMA-interacting protein 2|TTAGGG repeat-binding factor 1|telomeric protein Pin2/TRF1|telomeric repeat-binding factor 1 |
| Swissprots | Q93029 Q15553 Q8NHT6 A7XP29 P54274 |
| Accessions | ABV02580 EAW86990 EAW86991 EAW86992 EAW86993 EAW86994 P54274 AF003001 AAB81137 AI218408 AK123410 AK292529 BAF85218 AY576778 AAT81150 BC014646 BC029378 AAH29378 BC071975 BF056993 CX788828 DA658766 DQ892573 ABM83499 DQ895789 ABM86715 U40705 AAB54036 U74382 AAB53363 X93511 CAA63768 XM_005251291 XP_005251348 XM_005251292 XP_005251349 XM_011517582 XP_011515884 NM_003218 NP_003209 NM_017489 NP_059523 |
| Function | Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double- stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. {ECO:0000269|PubMed:16166375}. |
| Subcellular Location | Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle. |
| Tissue Specificity | Highly expressed and ubiquitous. Isoform Pin2 predominates. |
TRF1 CRISPR/Cas9 KO Plasmid (h) - sc-401433 from Santa Cruz Biotechnology
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TRF1 HDR Plasmid (h) - sc-401433-HDR from Santa Cruz Biotechnology
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TRF1 Double Nickase Plasmid (h) - sc-401433-NIC from Santa Cruz Biotechnology
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TRF1 Double Nickase Plasmid (h2) - sc-401433-NIC-2 from Santa Cruz Biotechnology
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TRF1 CRISPR Activation Plasmid (h) - sc-401433-ACT from Santa Cruz Biotechnology
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TRF1 CRISPR Activation Plasmid (h2) - sc-401433-ACT-2 from Santa Cruz Biotechnology
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TRF1 Lentiviral Activation Particles (h) - sc-401433-LAC from Santa Cruz Biotechnology
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TRF1 Lentiviral Activation Particles (h2) - sc-401433-LAC-2 from Santa Cruz Biotechnology
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TRF1 siRNA (h) - sc-36722 from Santa Cruz Biotechnology
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TRF1 shRNA Plasmid (h) - sc-36722-SH from Santa Cruz Biotechnology
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TRF1 shRNA (h) Lentiviral Particles - sc-36722-V from Santa Cruz Biotechnology
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TRF-1 RNAi - H00007013-R02 from Novus Biologicals
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TRF-1 RNAi - H00007013-R01 from Novus Biologicals
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MISSION® esiRNA - EHU114821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21218 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21218 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09697 from Sigma-Aldrich
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TERF1 siRNA (Human) - CRH4789 from Cohesion Biosciences
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TERF1 - MBS8221029 from MyBioSource
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TRF1 CRISPR/Cas9 KO Plasmid (h2) - sc-401433-KO-2 from Santa Cruz Biotechnology
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TRF1 HDR Plasmid (h2) - sc-401433-HDR-2 from Santa Cruz Biotechnology
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Human TERF1 siRNA - orb265291 from Biorbyt
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TERF1 shRNA Plasmid (Human) - CHH4789 from Cohesion Biosciences
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TERF1 miRNA 3'UTR clone - MiUTR3H-03764 from Creative biogene
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TERF1 miRNA 3'UTR clone - MiUTR3H-03765 from Creative biogene
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