| Gene Symbol |
CAV3
|
| Entrez Gene |
859
|
| Alt Symbol |
LGMD1C, LQT9, VIP-21, VIP21
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
caveolin 3
|
| Other Description |
M-caveolin|caveolin-3
|
| Swissprots |
Q3T1A4 A8K777 P56539
|
| Accessions |
AAC39758 AAG02025 EAW63945 EAW63946 P56539 AA993189 AF036365 AAC39756 AF043101 AAC14931 AK291892 BAF84581 BC069368 AAH69368 BC102033 AAI02034 BC102036 AAI02037 BC102037 AAI02038 BF310794 BX114193 Y14747 CAA75042 NM_001234 NP_001225 NM_033337 NP_203123
|
| Function |
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed predominantly in muscle. {ECO:0000269|PubMed:9545514}.
|
| Top Pathways |
Focal adhesion, Endocytosis, Bacterial invasion of epithelial cells, Proteoglycans in cancer
|