Gene Symbol | CAV3 |
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Entrez Gene | 859 |
Alt Symbol | LGMD1C, LQT9, VIP-21, VIP21 |
Species | Human |
Gene Type | protein-coding |
Description | caveolin 3 |
Other Description | M-caveolin|caveolin-3 |
Swissprots | Q3T1A4 A8K777 P56539 |
Accessions | AAC39758 AAG02025 EAW63945 EAW63946 P56539 AA993189 AF036365 AAC39756 AF043101 AAC14931 AK291892 BAF84581 BC069368 AAH69368 BC102033 AAI02034 BC102036 AAI02037 BC102037 AAI02038 BF310794 BX114193 Y14747 CAA75042 NM_001234 NP_001225 NM_033337 NP_203123 |
Function | May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). {ECO:0000250}. |
Tissue Specificity | Expressed predominantly in muscle. {ECO:0000269|PubMed:9545514}. |
Top Pathways | Focal adhesion, Endocytosis, Bacterial invasion of epithelial cells, Proteoglycans in cancer |
caveolin-3 CRISPR/Cas9 KO Plasmid (h) - sc-400569 from Santa Cruz Biotechnology
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caveolin-3 HDR Plasmid (h) - sc-400569-HDR from Santa Cruz Biotechnology
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caveolin-3 Double Nickase Plasmid (h) - sc-400569-NIC from Santa Cruz Biotechnology
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caveolin-3 Double Nickase Plasmid (h2) - sc-400569-NIC-2 from Santa Cruz Biotechnology
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caveolin-3 CRISPR Activation Plasmid (h) - sc-400569-ACT from Santa Cruz Biotechnology
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caveolin-3 CRISPR Activation Plasmid (h2) - sc-400569-ACT-2 from Santa Cruz Biotechnology
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caveolin-3 Lentiviral Activation Particles (h) - sc-400569-LAC from Santa Cruz Biotechnology
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caveolin-3 Lentiviral Activation Particles (h2) - sc-400569-LAC-2 from Santa Cruz Biotechnology
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caveolin-3 siRNA (h) - sc-29943 from Santa Cruz Biotechnology
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caveolin-3 shRNA Plasmid (h) - sc-29943-SH from Santa Cruz Biotechnology
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caveolin-3 shRNA (h) Lentiviral Particles - sc-29943-V from Santa Cruz Biotechnology
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Caveolin-3 RNAi - H00000859-R02 from Novus Biologicals
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Caveolin-3 RNAi - H00000859-R01 from Novus Biologicals
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MISSION® esiRNA - EHU063501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5404 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5404 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07376 from Sigma-Aldrich
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CAV3 siRNA (Human) - CRH0604 from Cohesion Biosciences
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CAV3 - MBS8235018 from MyBioSource
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caveolin-3 CRISPR/Cas9 KO Plasmid (h2) - sc-400569-KO-2 from Santa Cruz Biotechnology
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caveolin-3 HDR Plasmid (h2) - sc-400569-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CAV3 (NM_001234.4) - SHH255245 from Creative biogene
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Human CAV3 siRNA - orb261106 from Biorbyt
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CAV3 shRNA Plasmid (Human) - CHH0604 from Cohesion Biosciences
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CAV3 miRNA 3'UTR clone - MiUTR4H-TG01652 from Creative biogene
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