PODXL

Gene Symbol	PODXL
Entrez Gene	5420
Alt Symbol	Gp200, PC, PCLP, PCLP-1
Species	Human
Gene Type	protein-coding
Description	podocalyxin-like
Other Description	GCTM-2 antigen|podocalyxin|podocalyxin-like protein 1
Swissprots	Q53ER6 A6NHX8 O00592 Q52LZ7
Accessions	EAL24080 EAW83786 EAW83787 O00592 AK055816 BAB71022 AK223573 BAD97293 BC042466 BC093730 AAH93730 BC112035 AAI12036 BC143318 AAI43319 BG006197 BP355358 BX641124 CN290641 U97519 AAB61574 NM_001018111 NP_001018121 NM_005397 NP_005388
Function	Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell- cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR- dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {ECO:0000269|PubMed:17616675, ECO:0000269|PubMed:18456258}.
Subcellular Location	Apical cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus {ECO:0000250}. Membrane raft {ECO:0000250}. Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1 at the trans- Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Colocalizes with actin filaments, EZR and SLC9A3R1 in a punctate pattern at the apical cell surface where microvilli form. Colocalizes with EZR and SLC9A3R2 at the apical cell membrane of glomerular epithelium cells (By similarity). Forms granular, punctuated pattern, forming patches, preferentially adopting a polar distributi
Tissue Specificity	Glomerular epithelium cell (podocyte).

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse PODXL / Podocalyxin ELISA Kit (Sandwich ELISA) - LS-F6775 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.56 ng/ml Range 0.156-10 ng/ml

Human PODXL / Podocalyxin ELISA Kit (Sandwich ELISA) - LS-F4763 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Rat PODXL / Podocalyxin ELISA Kit (Sandwich ELISA) - LS-F9804 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 1.56 ng/ml Range 0.156-10 ng/ml

Human Podocalyxin ELISA Kit - abx051856 from Abbexa Category ELISA Kit

Human Podocalyxin ELISA Kit - abx152796 from Abbexa Category ELISA Kit Sensitivity 5.26 pg/ml Range 156.25 pg/ml - 10000 pg/ml

Podocalyxin, PCX, Human, ELISA Kit - E-EL-H2360 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Podocalyxin (PCX), Human, ELISA Kit - SEA768Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.053ng/mL Range 0.156-10ng/mL

Podocalyxin, Human, ELISA Kit - E01P0069 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 0.5-10ng/ml

Podocalyxin, PODXL, Human, ELISA Kit - E0768h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Podocalyxin, PCX, Mouse, ELISA Kit - E-EL-M0933 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Podocalyxin, PCX, Rat, ELISA Kit - E-EL-R0764 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.938 Range 1.563-100ng/mL

Podocalyxin, PCX, Rabbit, ELISA Kit - E-EL-RB0400 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Podocalyxin, PCX, Chicken, ELISA Kit - E-EL-Ch0036 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Podocalyxin, PCX, Porcine, ELISA Kit - E-EL-P0540 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Podocalyxin, PCX, Monkey, ELISA Kit - E-EL-MK1604 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

ELISA Kit for Podocalyxin (PCX) - SEA768Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Podocalyxin (PCX) - SEA768Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.56ng/mL. Range 1.56-100ng/mL The standard curve concentrations used for the ELISA’s were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.13ng/mL, 1.56ng/mL

ELISA Kit for Podocalyxin (PCX) - SEA768Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.59ng/mL. Range 1.56-100ng/mL The standard curve concentrations used for the ELISA’s were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.13ng/mL, 1.56ng/mL

Podocalyxin, ELISA Kit - MBS283140 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Podocalyxin, ELISA Kit - MBS007432 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Podocalyxin, ELISA Kit - MBS029192 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Podocalyxin, ELISA Kit - MBS035601 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Podocalyxin, ELISA Kit - MBS051986 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Podocalyxin, ELISA Kit - MBS045341 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Podocalyxin, ELISA Kit - MBS015909 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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