| Gene Symbol |
PODXL
|
| Entrez Gene |
5420
|
| Alt Symbol |
Gp200, PC, PCLP, PCLP-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
podocalyxin-like
|
| Other Description |
GCTM-2 antigen|podocalyxin|podocalyxin-like protein 1
|
| Swissprots |
Q53ER6 A6NHX8 O00592 Q52LZ7
|
| Accessions |
EAL24080 EAW83786 EAW83787 O00592 AK055816 BAB71022 AK223573 BAD97293 BC042466 BC093730 AAH93730 BC112035 AAI12036 BC143318 AAI43319 BG006197 BP355358 BX641124 CN290641 U97519 AAB61574 NM_001018111 NP_001018121 NM_005397 NP_005388
|
| Function |
Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell- cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR- dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {ECO:0000269|PubMed:17616675, ECO:0000269|PubMed:18456258}.
|
| Subcellular Location |
Apical cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus {ECO:0000250}. Membrane raft {ECO:0000250}. Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1 at the trans- Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Colocalizes with actin filaments, EZR and SLC9A3R1 in a punctate pattern at the apical cell surface where microvilli form. Colocalizes with EZR and SLC9A3R2 at the apical cell membrane of glomerular epithelium cells (By similarity). Forms granular, punctuated pattern, forming patches, preferentially adopting a polar distributi
|
| Tissue Specificity |
Glomerular epithelium cell (podocyte).
|
![Western Blot: Podocalyxin Overexpression Lysate (Adult Normal) [NBL1-14562] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Podocalyxin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/730_Podocalyxin%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14562-img0002.jpg)