PODXL

Gene Symbol	PODXL
Entrez Gene	5420
Alt Symbol	Gp200, PC, PCLP, PCLP-1
Species	Human
Gene Type	protein-coding
Description	podocalyxin-like
Other Description	GCTM-2 antigen|podocalyxin|podocalyxin-like protein 1
Swissprots	Q53ER6 A6NHX8 O00592 Q52LZ7
Accessions	EAL24080 EAW83786 EAW83787 O00592 AK055816 BAB71022 AK223573 BAD97293 BC042466 BC093730 AAH93730 BC112035 AAI12036 BC143318 AAI43319 BG006197 BP355358 BX641124 CN290641 U97519 AAB61574 NM_001018111 NP_001018121 NM_005397 NP_005388
Function	Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell- cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR- dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {ECO:0000269|PubMed:17616675, ECO:0000269|PubMed:18456258}.
Subcellular Location	Apical cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus {ECO:0000250}. Membrane raft {ECO:0000250}. Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1 at the trans- Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Colocalizes with actin filaments, EZR and SLC9A3R1 in a punctate pattern at the apical cell surface where microvilli form. Colocalizes with EZR and SLC9A3R2 at the apical cell membrane of glomerular epithelium cells (By similarity). Forms granular, punctuated pattern, forming patches, preferentially adopting a polar distributi
Tissue Specificity	Glomerular epithelium cell (podocyte).

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PODXL peptide - ab103266 from Abcam Category Peptide

PODXL / Podocalyxin Antibody Blocking Peptide - LS-E6310 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PODXL / Podocalyxin Antibody Blocking Peptide - LS-E16433 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PODXL / Podocalyxin Antibody Blocking Peptide - LS-E16434 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PODXL / Podocalyxin Antibody Blocking Peptide - LS-E26361 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Podocalyxin Like Blocking Peptide - NB110-41503PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

PODXL-Antibody-C-term-Blocking-Peptide - BP18999b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PODXL blocking peptide - GTX89038-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Recombinant Human Podocalyxin, CF - 1658-PD-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ser23-Arg427 and a C-terminal Asp and 10-His tag

Recombinant human Podocalyxin protein (OPCA00990) - OPCA00990 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Recombinant human Podocalyxin protein (OPCA01336) - OPCA01336 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human PODXL protein - orb245559 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human PODXL protein - orb246845 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

PODXL Blocking Peptide - 33R-6983 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PODXL Blocking Peptide - 33R-9335 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PODXL protein - 30R-3260 from Fitzgerald Category Protein Prices $210.00 Sizes 50 µg Source E.coli

Human Podocalyxin Protein - abx068614 from Abbexa Category Protein Source E.coli Species Human

PODXL Peptide - AC21-1196-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Podocalyxin (PCX), Human - 20-7075 from ARP American Research Products Category Protein Prices $481.00 Sizes 50 µg Source E.coli Species Human

PODXL Peptide - 46-206P from ProSci Category Peptide Species Human, Mouse, Rat

TRA-1-60 fusion protein - Ag12859 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

TRA-1-60 fusion protein - Ag12844 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human PODXL, GST-tagged - PODXL-1823H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human PODXL, Asp&His-tagged - PODXL-218H from Creative Biomart Category Protein Source NSO cells Species Human

Recombinant Podocalyxin (PCX) - RPA768Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

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