Gene Symbol | SCN7A |
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Entrez Gene | 6332 |
Alt Symbol | NaG, Nav2.1, Nav2.2, SCN6A |
Species | Human |
Gene Type | protein-coding |
Description | sodium channel, voltage gated, type VII alpha subunit |
Other Description | putative voltage-gated sodium channel subunit alpha Nax|sodium channel protein cardiac and skeletal muscle subunit alpha|sodium channel protein type 7 subunit alpha|sodium channel protein type VII subunit alpha|sodium channel, voltage-gated, type VI, alpha polypeptide|sodium channel, voltage-gated, type VII, alpha subunit|voltage-dependent sodium channel alpha subunit |
Swissprots | Q01118 |
Accessions | EAX11312 EAX11313 Q01118 AK308450 BC062699 BC141864 CF129950 CK903677 M91556 AAA59899 S75992 AAD14203 XM_006712680 XP_006712743 XM_006712681 XP_006712744 XM_006712682 XP_006712745 XM_011511615 XP_011509917 NM_002976 NP_002967 NR_045628 |
Function | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Heart and uterus. |
Top Pathways | Adrenergic signaling in cardiomyocytes |
Na + CP type VIIα CRISPR/Cas9 KO Plasmid (h) - sc-406404 from Santa Cruz Biotechnology
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Na + CP type VIIα HDR Plasmid (h) - sc-406404-HDR from Santa Cruz Biotechnology
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Na + - sc-406404-NIC from Santa Cruz Biotechnology
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Na + - sc-406404-NIC-2 from Santa Cruz Biotechnology
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Na + - sc-406404-ACT from Santa Cruz Biotechnology
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Na + - sc-406404-ACT-2 from Santa Cruz Biotechnology
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Na + - sc-406404-LAC from Santa Cruz Biotechnology
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Na + - sc-406404-LAC-2 from Santa Cruz Biotechnology
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Na + CP type VIIα siRNA (h) - sc-94349 from Santa Cruz Biotechnology
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Na + CP type VIIα shRNA Plasmid (h) - sc-94349-SH from Santa Cruz Biotechnology
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Na + CP type VIIα shRNA (h) Lentiviral Particles - sc-94349-V from Santa Cruz Biotechnology
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SCN7A RNAi - H00006332-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN18957 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18957 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05598 from Sigma-Aldrich
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SCN7A siRNA (Human) - CRH4268 from Cohesion Biosciences
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SCN7A - MBS8210021 from MyBioSource
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shRNA set against Human SCN7A (NM_002976.3) - SHH402892 from Creative biogene
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SCN7A shRNA Plasmid (Human) - CHH4268 from Cohesion Biosciences
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SCN7A miRNA 3'UTR clone - MiUTR3H-02117 from Creative biogene
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