LRRC16A

Gene Symbol LRRC16A
Entrez Gene 55604
Alt Symbol CARMIL, CARMIL1, CARMIL1a, LRRC16, dJ501N12.1, dJ501N12.5
Species Human
Gene Type protein-coding
Description leucine rich repeat containing 16A
Other Description CARMIL homolog|capping protein, Arp2/3, and Myosin-I Linker homolog 1|leucine rich repeat containing 16|leucine-rich repeat-containing protein 16A
Swissprots Q6ZW07 B8X1J0 Q6ZUH5 Q5VZK9 Q9NXU7
Accessions Q5VZK9 AI142012 AK000055 BAA90912 AK123817 BAC85701 AK125696 BAC86250 AK225208 BC040903 AAH40903 BC140770 AAI40771 BC172272 AAI72272 BC172573 AAI72573 BE765272 BF330246 BG978388 BQ423885 CB132825 CD691491 CN283219 CV330537 FJ009082 ACI49709 Y10210 Y10508 Y10514 Y10518 Y10519 Z83935 Z83950 XM_005249218 XP_005249275 XM_011514732 XP_011513034 XM_011514733 XP_011513035 XM_011514734 XP_011513036 XM_011514735 XP_011513037 XM_011514736 XP_011513038 XM_011514737 XP_011513039 NM_001173977 NP_001167448 NM_017640 NP_060110
Function Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization (By similarity). May control actin dynamics in lamellipodia. Required for cell migration. {ECO:0000250, ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}.
Subcellular Location Cell projection, lamellipodium {ECO:0000269|PubMed:19846667}. Cytoplasm {ECO:0000269|PubMed:19846667}. Note=Colocalized with F-actin in lamellipodia but not with F-actin in stress fibers. Also found on macropinosomes.
Tissue Specificity Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney. {ECO:0000269|PubMed:16054028}.

CARMIL (E-10) - sc-365314 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CARMIL (E-10): sc-365314. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tissue showing nuclear envelope and nuclear staining of glandular cells.

CARMIL (H-300) - sc-67364 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

CARMIL (K-20) - sc-67466 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CARMIL (K-20): sc-67466. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and nuclear localization.

Anti-CARMIL antibody - ab52681 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-CARMIL antibody (ab52681) at 1/1000 dilutionLane 1 : Total protein extract from E coli with 50ng to 100 ng of a tagged fusion protein of an irrelevant antigen.Lane 2 : Total protein extract from E coli with 50ng to 500ng of the antigen (tagged antigen fusion protein)Lysates/proteins at 20 µg per lane.SecondaryRabbit anti-mouse IgG + IgM, HRP conjugated, at 1/5000 dilution

Anti-CARMIL antibody - C-terminal - ab173846 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CARMIL antibody - C-terminal (ab173846) at 1/100 dilution + Mouse stomach tissue lysate at 35 µg

Anti-LRRC16 / CARMIL Antibody (aa1152-1178, AP) - LS-C262145 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LRRC16 / CARMIL Antibody (aa1152-1178, APC) - LS-C262146 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LRRC16 / CARMIL Antibody (aa1152-1178, Biotin) - LS-C262147 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LRRC16 / CARMIL Antibody (aa1152-1178, FITC) - LS-C262148 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LRRC16 / CARMIL Antibody (aa1152-1178, Azide-free, HRP) - LS-C262149 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LRRC16 / CARMIL Antibody (aa1152-1178, PE) - LS-C262150 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LRRC16 / CARMIL Antibody (aa1151-1178) - LS-C322720 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LRRC16 / CARMIL Antibody (aa1152-1178) - LS-C158071 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
LRRC16A Antibody western blot of mouse stomach tissue lysates (35 ug/lane). The LRRC16A antibody detected the LRRC16A protein (arrow).

LRRC16A Antibody - NBP1-91222 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: LRRC16A Antibody [NBP1-91222] - Immunofluorescent staining of human cell line A-431 shows localization to cytosol.

LRRC16A Antibody - NBP1-91221 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: LRRC16A Antibody [NBP1-91221] - Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear speckles & cytosol.

LRRC16A-Antibody-C-term - AP18234b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
LRRC16A Antibody (C-term) (Cat. #AP18234b) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the LRRC16A antibody detected the LRRC16A protein (arrow).

LRRC16A Antibody - C-terminal region (OAAB13748) - OAAB13748 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

LRRC16A Antibody - abx030121 from Abbexa

Host Rabbit
Clonality Polyclonal
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