| Gene Symbol |
LRRC16A
|
| Entrez Gene |
55604
|
| Alt Symbol |
CARMIL, CARMIL1, CARMIL1a, LRRC16, dJ501N12.1, dJ501N12.5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine rich repeat containing 16A
|
| Other Description |
CARMIL homolog|capping protein, Arp2/3, and Myosin-I Linker homolog 1|leucine rich repeat containing 16|leucine-rich repeat-containing protein 16A
|
| Swissprots |
Q6ZW07 B8X1J0 Q6ZUH5 Q5VZK9 Q9NXU7
|
| Accessions |
Q5VZK9 AI142012 AK000055 BAA90912 AK123817 BAC85701 AK125696 BAC86250 AK225208 BC040903 AAH40903 BC140770 AAI40771 BC172272 AAI72272 BC172573 AAI72573 BE765272 BF330246 BG978388 BQ423885 CB132825 CD691491 CN283219 CV330537 FJ009082 ACI49709 Y10210 Y10508 Y10514 Y10518 Y10519 Z83935 Z83950 XM_005249218 XP_005249275 XM_011514732 XP_011513034 XM_011514733 XP_011513035 XM_011514734 XP_011513036 XM_011514735 XP_011513037 XM_011514736 XP_011513038 XM_011514737 XP_011513039 NM_001173977 NP_001167448 NM_017640 NP_060110
|
| Function |
Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization (By similarity). May control actin dynamics in lamellipodia. Required for cell migration. {ECO:0000250, ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}.
|
| Subcellular Location |
Cell projection, lamellipodium {ECO:0000269|PubMed:19846667}. Cytoplasm {ECO:0000269|PubMed:19846667}. Note=Colocalized with F-actin in lamellipodia but not with F-actin in stress fibers. Also found on macropinosomes.
|
| Tissue Specificity |
Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney. {ECO:0000269|PubMed:16054028}.
|