LRRC16A

Gene Symbol LRRC16A
Entrez Gene 55604
Alt Symbol CARMIL, CARMIL1, CARMIL1a, LRRC16, dJ501N12.1, dJ501N12.5
Species Human
Gene Type protein-coding
Description leucine rich repeat containing 16A
Other Description CARMIL homolog|capping protein, Arp2/3, and Myosin-I Linker homolog 1|leucine rich repeat containing 16|leucine-rich repeat-containing protein 16A
Swissprots Q6ZW07 B8X1J0 Q6ZUH5 Q5VZK9 Q9NXU7
Accessions Q5VZK9 AI142012 AK000055 BAA90912 AK123817 BAC85701 AK125696 BAC86250 AK225208 BC040903 AAH40903 BC140770 AAI40771 BC172272 AAI72272 BC172573 AAI72573 BE765272 BF330246 BG978388 BQ423885 CB132825 CD691491 CN283219 CV330537 FJ009082 ACI49709 Y10210 Y10508 Y10514 Y10518 Y10519 Z83935 Z83950 XM_005249218 XP_005249275 XM_011514732 XP_011513034 XM_011514733 XP_011513035 XM_011514734 XP_011513036 XM_011514735 XP_011513037 XM_011514736 XP_011513038 XM_011514737 XP_011513039 NM_001173977 NP_001167448 NM_017640 NP_060110
Function Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization (By similarity). May control actin dynamics in lamellipodia. Required for cell migration. {ECO:0000250, ECO:0000269|PubMed:16054028, ECO:0000269|PubMed:19846667}.
Subcellular Location Cell projection, lamellipodium {ECO:0000269|PubMed:19846667}. Cytoplasm {ECO:0000269|PubMed:19846667}. Note=Colocalized with F-actin in lamellipodia but not with F-actin in stress fibers. Also found on macropinosomes.
Tissue Specificity Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney. {ECO:0000269|PubMed:16054028}.

CARMIL CRISPR/Cas9 KO Plasmid (h) - sc-406136 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CARMIL HDR Plasmid (h) - sc-406136-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CARMIL Double Nickase Plasmid (h) - sc-406136-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CARMIL Double Nickase Plasmid (h2) - sc-406136-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CARMIL CRISPR Activation Plasmid (h) - sc-406136-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CARMIL CRISPR Activation Plasmid (h2) - sc-406136-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CARMIL Lentiviral Activation Particles (h) - sc-406136-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CARMIL Lentiviral Activation Particles (h2) - sc-406136-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CARMIL siRNA (h) - sc-62080 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CARMIL shRNA Plasmid (h) - sc-62080-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CARMIL shRNA (h) Lentiviral Particles - sc-62080-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU093081 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN12708 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07717 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07717

LRRC16A siRNA (Human) - CRJ0765 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LRRC16A (NM_017640.5) - SHH334211 from Creative biogene

Category siRNA
Species Reactivities Human

Human LRRC16A siRNA - orb271266 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LRRC16A shRNA Plasmid (Human) - CHJ0765 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LRRC16A miRNA 3'UTR clone - MiUTR3H-10700 from Creative biogene

Species Reactivities Human
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