| Gene Symbol |
RGS7BP
|
| Entrez Gene |
401190
|
| Alt Symbol |
R7BP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
regulator of G-protein signaling 7 binding protein
|
| Other Description |
R7 family-binding protein|regulator of G-protein signaling 7-binding protein
|
| Swissprots |
B7Z3X1 Q6MZT1
|
| Accessions |
EAW51372 Q6MZT1 AK294808 BAG57927 AK296443 BAH12357 AK296494 BAG59129 BC140707 AAI40708 BX640900 CAE45947 DA211241 DA404068 DA417118 DC342795 XM_005248502 XP_005248559 XR_948251 NM_001029875 NP_001025046 NM_001271890 NP_001258819 NM_001271891 NP_001258820 NR_073511
|
| Function |
Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation. {ECO:0000250}.
|