Gene Symbol | RGS7BP |
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Entrez Gene | 401190 |
Alt Symbol | R7BP |
Species | Human |
Gene Type | protein-coding |
Description | regulator of G-protein signaling 7 binding protein |
Other Description | R7 family-binding protein|regulator of G-protein signaling 7-binding protein |
Swissprots | B7Z3X1 Q6MZT1 |
Accessions | EAW51372 Q6MZT1 AK294808 BAG57927 AK296443 BAH12357 AK296494 BAG59129 BC140707 AAI40708 BX640900 CAE45947 DA211241 DA404068 DA417118 DC342795 XM_005248502 XP_005248559 XR_948251 NM_001029875 NP_001025046 NM_001271890 NP_001258819 NM_001271891 NP_001258820 NR_073511 |
Function | Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation. {ECO:0000250}. |
R7BP CRISPR/Cas9 KO Plasmid (h) - sc-415971 from Santa Cruz Biotechnology
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R7BP HDR Plasmid (h) - sc-415971-HDR from Santa Cruz Biotechnology
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R7BP Double Nickase Plasmid (h) - sc-415971-NIC from Santa Cruz Biotechnology
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R7BP Double Nickase Plasmid (h2) - sc-415971-NIC-2 from Santa Cruz Biotechnology
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R7BP CRISPR Activation Plasmid (h) - sc-415971-ACT from Santa Cruz Biotechnology
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R7BP CRISPR Activation Plasmid (h2) - sc-415971-ACT-2 from Santa Cruz Biotechnology
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R7BP Lentiviral Activation Particles (h) - sc-415971-LAC from Santa Cruz Biotechnology
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R7BP Lentiviral Activation Particles (h2) - sc-415971-LAC-2 from Santa Cruz Biotechnology
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R7BP siRNA (h) - sc-61431 from Santa Cruz Biotechnology
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R7BP shRNA Plasmid (h) - sc-61431-SH from Santa Cruz Biotechnology
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R7BP shRNA (h) Lentiviral Particles - sc-61431-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU097181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18233 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18233 from Sigma-Aldrich
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RGS7BP siRNA (Human) - CRJ8118 from Cohesion Biosciences
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RGS7BP - MBS8232839 from MyBioSource
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shRNA set against Human RGS7BP (NM_001029875.1) - SHH395024 from Creative biogene
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shRNA set against Human RGS7BP(NM_001029875.1) - SHR179682 from Creative biogene
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Human RGS7BP siRNA - orb278619 from Biorbyt
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RGS7BP shRNA Plasmid (Human) - CHJ8118 from Cohesion Biosciences
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RGS7BP miRNA 3'UTR clone - MiUTR1H-08795 from Creative biogene
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