Gene Symbol |
COMMD8
|
Entrez Gene |
54951
|
Alt Symbol |
-
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
COMM domain containing 8
|
Other Description |
COMM domain-containing protein 8
|
Swissprots |
Q9HC15 Q9NX08 Q8WUR4
|
Accessions |
EAW93033 EAW93034 Q9NX08 AF182421 AAG14957 AK000509 BAA91216 AY542163 AAS22245 BC008371 AAH08371 BC015145 AAH15145 BC019826 AAH19826 HQ447967 ADQ32450 XM_006714019 XP_006714082 NM_017845 NP_060315
|
Function |
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). {ECO:0000269|PubMed:15799966, ECO:0000305|PubMed:21778237}.
|
Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:21778237}. Nucleus {ECO:0000269|PubMed:21778237}.
|
Tissue Specificity |
Widely expressed with highest expression in thyroid. {ECO:0000269|PubMed:15799966}.
|