Gene Symbol | COMMD8 |
---|---|
Entrez Gene | 54951 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | COMM domain containing 8 |
Other Description | COMM domain-containing protein 8 |
Swissprots | Q9HC15 Q9NX08 Q8WUR4 |
Accessions | EAW93033 EAW93034 Q9NX08 AF182421 AAG14957 AK000509 BAA91216 AY542163 AAS22245 BC008371 AAH08371 BC015145 AAH15145 BC019826 AAH19826 HQ447967 ADQ32450 XM_006714019 XP_006714082 NM_017845 NP_060315 |
Function | May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). {ECO:0000269|PubMed:15799966, ECO:0000305|PubMed:21778237}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21778237}. Nucleus {ECO:0000269|PubMed:21778237}. |
Tissue Specificity | Widely expressed with highest expression in thyroid. {ECO:0000269|PubMed:15799966}. |