Gene Symbol | SNRNP200 |
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Entrez Gene | 23020 |
Alt Symbol | ASCC3L1, BRR2, HELIC2, RP33, U5-200KD |
Species | Human |
Gene Type | protein-coding |
Description | small nuclear ribonucleoprotein 200kDa (U5) |
Other Description | BRR2 homolog|U5 small nuclear ribonucleoprotein 200 kDa helicase|U5 snRNP-specific 200 kDa protein|activating signal cointegrator 1 complex subunit 3-like 1 |
Swissprots | Q9H7S0 O94884 Q6PX59 Q6NZY0 Q96IF2 O75643 Q8NBE6 |
Accessions | CAA94089 EAW71372 EAW71373 O75643 AB018331 BAA34508 AF085356 AAD40191 AF119874 AAF69628 AJ844618 CAH59741 AK021418 AK021583 AK023840 BAB14698 AK024391 BAB14906 AK026662 AK090671 BAC03499 AK303465 BAG64507 AK303663 BAG64662 AL831994 AW190145 AY572488 AAS78571 BC001417 AAH01417 BC007577 AAH07577 BC065924 AAH65924 BC112891 AAI12892 BC131784 AAI31785 BP873066 DA109508 DB067751 NM_014014 NP_054733 |
Function | RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:23045696, ECO:0000269|PubMed:8670905, ECO:0000269|PubMed:9539711}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:9539711}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:19878916}. |
Top Pathways | Spliceosome |
HELIC2 CRISPR/Cas9 KO Plasmid (h) - sc-404491 from Santa Cruz Biotechnology
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HELIC2 HDR Plasmid (h) - sc-404491-HDR from Santa Cruz Biotechnology
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HELIC2 Double Nickase Plasmid (h) - sc-404491-NIC from Santa Cruz Biotechnology
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HELIC2 Double Nickase Plasmid (h2) - sc-404491-NIC-2 from Santa Cruz Biotechnology
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HELIC2 CRISPR Activation Plasmid (h) - sc-404491-ACT from Santa Cruz Biotechnology
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HELIC2 CRISPR Activation Plasmid (h2) - sc-404491-ACT-2 from Santa Cruz Biotechnology
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HELIC2 Lentiviral Activation Particles (h) - sc-404491-LAC from Santa Cruz Biotechnology
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HELIC2 Lentiviral Activation Particles (h2) - sc-404491-LAC-2 from Santa Cruz Biotechnology
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HELIC2 siRNA (h) - sc-75243 from Santa Cruz Biotechnology
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HELIC2 shRNA Plasmid (h) - sc-75243-SH from Santa Cruz Biotechnology
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HELIC2 shRNA (h) Lentiviral Particles - sc-75243-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU065401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20258 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20258 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06148 from Sigma-Aldrich
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SNRNP200 siRNA (Human) - CRH7935 from Cohesion Biosciences
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ASCC3L1 RNAi - H00023020-R02 from Novus Biologicals
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SNRNP200 - MBS829146 from MyBioSource
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shRNA set against Human SNRNP200 (NM_014014.4) - SHH414224 from Creative biogene
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Human SNRNP200 siRNA - orb268437 from Biorbyt
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SNRNP200 shRNA Plasmid (Human) - CHH7935 from Cohesion Biosciences
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SNRNP200 miRNA 3'UTR clone - MiUTR3H-04305 from Creative biogene
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