| Gene Symbol |
EIF2D
|
| Entrez Gene |
1939
|
| Alt Symbol |
HCA56, LGTN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 2D
|
| Other Description |
hepatocellular carcinoma-associated antigen 56|ligatin
|
| Swissprots |
Q9NSN0 Q9NR27 Q8IXV3 Q9NZ21 Q5SY40 Q96TG7 Q96DG3 P41214 Q9NV18
|
| Accessions |
EAW93536 EAW93537 EAW93538 EAW93539 EAW93540 P41214 AB209364 BAD92601 AF159586 AAD41909 AF220417 AAF34185 AF262403 AAF74205 AK001852 BAA91942 AK225259 AK294536 BAG57743 AL162001 CAB82330 BC001585 AAH01585 BC039134 AAH39134 BC058905 AAH58905 BI465059 DC399556 DQ580499 DQ891590 ABM82516 DQ894784 ABM85710 XM_005277509 XP_005277566 XM_006711196 XP_006711259 XM_011509257 XP_011507559 XM_011509258 XP_011507560 XR_921750 XR_921751 NM_001201478 NP_001188407 NM_006893 NP_008824
|
| Function |
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P- site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. {ECO:0000269|PubMed:20566627, ECO:0000269|PubMed:20713520}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:20566627}.
|
![Western Blot: LGTN Overexpression Lysate (Adult Normal) [NBL1-12510] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LGTN.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5846_LGTN%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12510-img0002.jpg)