NACC1

Gene Symbol	NACC1
Entrez Gene	112939
Alt Symbol	BEND8, BTBD14B, BTBD30, NAC-1, NAC1
Species	Human
Gene Type	protein-coding
Description	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
Other Description	BEN domain containing 8\|BTB/POZ domain-containing protein 14B\|nucleus accumbens-associated protein 1\|transcriptional repressor NAC1
Swissprots	Q96RE7
Accessions	EAW84352 EAW84353 EAW84354 Q96RE7 AF395817 AAK83885 AK094702 AK123056 AK226064 BC055396 AAH55396 BU508302 BU623112 BX395451 XM_005259721 XP_005259778 NM_052876 NP_443108
Function	Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. {ECO:0000269\|PubMed:17130457, ECO:0000269\|PubMed:17804717}.
Subcellular Location	Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation. {ECO:0000250}.
Tissue Specificity	Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer. {ECO:0000269\|PubMed:17130457, ECO:0000269\|PubMed:17391728}.

NAC1 Antibody (Human Preferred) - 4420 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from various tissue and cell lines using NAC1 Antibody (Human Preferred).

NAC1 Antibody (Rodent Preferred) - 4183 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from adult mouse brain using NAC1 Antibody (Rodent Preferred).

BTBD14B (E-3) - sc-376216 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

BTBD14B (E-3): sc-376216. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

BTBD14B (H-74) - sc-98638 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

BTBD14B (H-74): sc-98638. Western blot analysis of BTBD14B expression in non-transfected: sc-117752 (A) and human BTBD14B transfected: sc-116444 (B) 293T whole cell lysates.

BTBD14B (S-15) - sc-109928 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

BTBD14B (S-15): sc-109928. Western blot analysis of BTBD14B expression in non-transfected: sc-117752 (A) and human BTBD14B transfected: sc-116444 (B) 293T whole cell lysates.

Anti-Nac1 antibody - ab29047 from Abcam

Prices	$385.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Nac1 antibody (ab29047) at 1/250 dilutionLane 1 : F9 (Mouse embryonic carcinoma cell line) Whole Cell Lysate (ab27193)Lane 2 : IOUD2 (Mouse embryonic stem cell, selected for Oct4 expression cell line) Whole Cell Lysate (ab27202)Lane 3 : F9 (Mouse embryonic carcinoma cell line) Whole Cell Lysate (ab27193) with Nac1 peptide (ab30604) at 1 µg/mlLane 4 : IOUD2 (Mouse embryonic stem cell, selected for Oct4 expression cell line) Whole Cell Lysate (ab27202) with Nac1 peptide (ab30604) at 1 µg/mlLysates/proteins at 20 µg per lane.SecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-Nac1 antibody - ab80144 from Abcam

Prices	$376.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ab80144 at a dilution of 1/10, peroxidase-conjugated to the secondary antibody, followed by DAB staining.

Anti-Nac1 antibody [6H2] - ab107241 from Abcam

Host	Mouse
Clonality	Monoclonal
Clone	6H2

All lanes : Anti-Nac1 antibody [6H2] (ab107241) at 1/500 dilutionLane 1 : HEK293 cell lysateLane 2 : Nac1-hIgGFc transfected HEK293 cell lysate

Anti-NACC1 / NAC1 Antibody (clone 6H2) - LS-C169287 from LifeSpan Bioscience

Prices	$345.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	6H2

IHC of paraffin-embedded mammary cancer tissues (left) and ovarian cancer tissues (right) using NACC1 mouse monoclonal antibody with DAB staining.

Anti-NACC1 / NAC1 Antibody - LS-C131118 from LifeSpan Bioscience

Prices	$445.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NACC1 / NAC1 Antibody (C-Terminus) - LS-C131119 from LifeSpan Bioscience

Prices	$445.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NACC1 / NAC1 Antibody (clone 3, Biotin) - LS-C141408 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3

Anti-NACC1 / NAC1 Antibody (clone 3, DY488) - LS-C141410 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3

Anti-NACC1 / NAC1 Antibody (clone 3, DY650) - LS-C141409 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3

Anti-NACC1 / NAC1 Antibody (clone 3, HRP) - LS-C141411 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3

Anti-NACC1 / NAC1 Antibody (clone 3, DY550) - LS-C141412 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3

Anti-NACC1 / NAC1 Antibody (aa291-340) - LS-C31237 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

NACC1 / NAC-1 antibody LS-C31237 was used in IHC to stain formalin-fixed, paraffin-embedded human lung.

Anti-NACC1 / NAC1 Antibody (aa252-301) - LS-C109949 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

NACC1 / NAC-1 antibody LS-C109949 Western blot of 721_B cell lysate.

Anti-NACC1 / NAC1 Antibody (aa167-178) - LS-C55141 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Antibody (0.5 ug/ml) staining of Human Bone Marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-NACC1 / NAC1 Antibody (C-Terminus) - LS-C31236 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

NACC1 / NAC-1 antibody LS-C31236 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.

Anti-NACC1 / NAC1 Antibody (aa519-523) - LS-C205219 from LifeSpan Bioscience

Prices	$265.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts from Rat and Mouse brain tissue using NAC1 antibody.

Anti-NACC1 / NAC1 Antibody (clone 3) - LS-C141804 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3

NAC1 Antibody - Nuclear staining of paraffin-embedded ovarian cancer cells.

NAC1 Antibody (3) - NB110-77345 from Novus Biologicals

Prices	$99.00, $279.00
Sizes	25 µl, 100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3

Western Blot: Nac1 Antibody (3) [NB110-77345] - Detection of NAC-1 in HeLa nuclear extracts.

NAC1 Antibody - NBP1-89991 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunocytochemistry/Immunofluorescence: Nac1 Antibody [NBP1-89991] Staining of human cell line U-2 OS shows positivity in nucleus but not nucleoli.

NAC1 Antibody (6H2) - NBP1-51681 from Novus Biologicals

Prices	$349.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	6H2

Western Blot: NAC1 Antibody (6H2) [NBP1-51681] - Western blot analysis using NACC1 mAb against HEK293 (1) and NACC1-hIgGFc transfected HEK293 (2) cell lysate.

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