| Gene Symbol |
NACC1
|
| Entrez Gene |
112939
|
| Alt Symbol |
BEND8, BTBD14B, BTBD30, NAC-1, NAC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
|
| Other Description |
BEN domain containing 8|BTB/POZ domain-containing protein 14B|nucleus accumbens-associated protein 1|transcriptional repressor NAC1
|
| Swissprots |
Q96RE7
|
| Accessions |
EAW84352 EAW84353 EAW84354 Q96RE7 AF395817 AAK83885 AK094702 AK123056 AK226064 BC055396 AAH55396 BU508302 BU623112 BX395451 XM_005259721 XP_005259778 NM_052876 NP_443108
|
| Function |
Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. {ECO:0000269|PubMed:17130457, ECO:0000269|PubMed:17804717}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation. {ECO:0000250}.
|
| Tissue Specificity |
Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer. {ECO:0000269|PubMed:17130457, ECO:0000269|PubMed:17391728}.
|